Oxidative Stress in Acute Myocardial Infarction Patients-Reference-Cited by-同舟云学术

Oxidative Stress in Acute Myocardial Infarction Patients

Published:2024-03-01 Issue:1 Volume:25 Page:51-56
ISSN:2956-2090
Container-title:Experimental and Applied Biomedical Research (EABR)
language:en
Short-container-title:

Author:

Jovanovic Jovan¹,Pantic Katarina²,Milojevic Dragan³,Milojevic Andjela⁴,Canovic Petar⁵,Zaric Milan⁵,Zdravkovic Natasa⁶⁷,Andjelkovic Marija⁵,Ravic Marko⁸,Miloradovic Vladimir⁶¹

Affiliation:

1. Clinic of Cardiology , University Clinical Center Kragujevac , Kragujevac , Serbia

2. Clinic of Pulmolonogy , University Clinical Center Kragujevac , Kragujevac , Serbia

3. Institute for Emergency Medical Aid , Kragujevac , Serbia

4. University of Kragujevac, Faculty of Medical Sciences , Department of Dentistry , Kragujevac , Serbia

5. University of Kragujevac, Faculty of Medical Sciences , Department of Biochemistry , Kragujevac , Serbia

6. University of Kragujevac, Faculty of Medical Sciences , Department of Internal Medicine , Kragujevac , Serbia

7. Clinic of Internal Medicine , University Clinical Centre “Kragujevac” , Kragujevac , Serbia

8. University of Kragujevac, Faculty of Medical Sciences , Department of Clinical Pharmacy , Kragujevac , Serbia

Abstract

Abstract The aim of this study was to assess and compare the oxidative stress status in STEMI and NSTEMI patients by measuring markers of free radical production and levels of antioxidant. The research was designed as an observational study with a cohort of 83 AMI hospitalized patients divided into a case (STEMI) and control (NSTEMI) group. In the study, we used the data from the patients’ electronic medical records and paper files and two scores (TIMI, and GRACE) analyzed routine biochemical parameters and biochemical assays for ROS. The statistical analysis included descriptive methods, hypothesis testing and bivariate correlation. In our research, the results clearly showed that patients with STEMI had an increased activity of vSOD compared with NSTEMI patients (p<0.01). Also, the levels of TBARS in plasma of patients with STEMI were significantly increased compared to the NSTEMI patients (p<0.01). Importantly, there were no differences between STEMI patients and NSTEMI patients, for the levels of O2 −, H2O2, NO, CAT, GSH. In STEMI patients, we found a positive correlation between TBARS and troponin level and a positive correlation between SOD and troponin level. In addition, our results also showed a positive correlation between AST levels and TBARS and a positive correlation between AST levels and SOD. We also found a positive correlation between GRACE score values and TBARS and SOD. Our study demonstrated that the levels of TBARS and SOD were significantly higher in STEMI patients than in NSTEMI.

Publisher

Walter de Gruyter GmbH

Link

https://www.sciendo.com/pdf/10.2478/sjecr-2021-0008

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