Simple UV Spectrophotometric Determination of Rosuvastatin Calcium in Pure Form and in Pharmaceutical Formulations-Reference-Cited by-同舟云学术

Simple UV Spectrophotometric Determination of Rosuvastatin Calcium in Pure Form and in Pharmaceutical Formulations

Published:2009 Issue:1 Volume:6 Page:89-92
ISSN:0973-4945
Container-title:E-Journal of Chemistry
language:en
Short-container-title:E-Journal of Chemistry

Author:

Gupta Alka¹²,Mishra P.³,Shah K.³

Affiliation:

1. Department of Pharmaceutical Sciences, Dr. H.S. Gour Vishwavidyalaya, Sagar (M.P.), India

2. IPS College of Pharmacy, Gwalior (M.P.), India

3. GLA Institute of Pharmaceutical Research, Mathura-(U.P.), India

Abstract

A new, simple and sensitive spectrophotometric method in ultraviolet region has been developed for the determination of rosuvastatin calcium in bulk and in pharmaceutical formulations. Rosuvastatin exhibits absorption maxima at 244 nm with apparent molar absorptivity of 7.2345 ×104L/mol.cm in methanol. Beer’s law was found to be obeyed in the concentration range of 2-18 µg/mL. The method is accurate, precise and economical. This method is extended to pharmaceutical preparations. In this method, there is no interference from any common pharmaceutical additives and diluents. Results of the analysis were validated statistically and by recovery studies

Funder

All India Council for Technical Education

Publisher

Hindawi Limited

Subject

General Chemistry

Link

http://downloads.hindawi.com/journals/jchem/2009/956712.pdf

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