Neutrophils in Tuberculosis: Heterogeneity Shapes the Way?

Abstract

Infection withM. tuberculosisremains one of the most common infections in the world. The outcome of the infection depends on host ability to mount effective protection and balance inflammatory responses. Neutrophils are innate immune cells implicated in both processes. Accordingly, duringM. tuberculosisinfection, they play a dual role. Particularly, they contribute to the generation of effector T cells, participate in the formation of granuloma, and are directly involved in tissue necrosis, destruction, and infection dissemination. Neutrophils have a high bactericidal potential. However, data on their ability to eliminateM. tuberculosisare controversial, and the results of neutrophil depletion experiments are not uniform. Thus, the overall roles of neutrophils duringM. tuberculosisinfection and factors that determine these roles are not fully understood. This review analyzes data on neutrophil defensive and pathological functions during tuberculosis and considers hypotheses explaining the dualism of neutrophils duringM. tuberculosisinfection and tuberculosis disease.