Catalpol Induces Neuroprotection and Prevents Memory Dysfunction through the Cholinergic System and BDNF

Author:

Wan Dong1,Xue LiJun2,Zhu HuiFeng34,Luo Yong5

Affiliation:

1. Department of Emergency, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China

2. Chongqing Chemical Industry Vocational College, 400020, China

3. College of Pharmaceutical Sciences and Traditional Chinese Medicine, Southwest University, Chongqing 400715, China

4. Chongqing Engineering Research Center for Pharmacological Evaluation, Chongqing 400715, China

5. Department of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China

Abstract

To investigate the role and mechanism of catalpol on neuroprotective effects and memory enhancing effects simultaneously, neuroprotective effects of catalpol were assessed by neurological deficits score, TTC staining, and cerebral blood flow detecting. Morris water maze was employed to investigate its effects on learning and memory and then clarify its possible mechanisms relating the central cholinergic system and BDNF. Edaravone and oxiracetam were used for positive control drugs based on its different action. Results showed that catalpol and edaravone significantly facilitated neurological function recovery, reduced infarction volume, and increased cerebral blood flow in stroke mice. Catalpol and oxiracetam decreased the escape latency significantly and increased the numbers of crossing platform obviously. The levels of ACh, ChAT, and BDNF in catalpol group were increased in a dose-dependent manner, and AChE declined with a U-shaped dose-response curve. Moreover, the levels of muscarinic AChR subtypes M1and M2in hippocampus were considerably raised by catalpol. These results demonstrated that catalpol may be useful for neuroprotection and memory enhancement, and the mechanism may be related to the central cholinergic system.

Funder

National Natural Science Foundation of China

Publisher

Hindawi Limited

Subject

Complementary and alternative medicine

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