Regulation of Human Cytochrome P4501A1 (hCYP1A1): A Plausible Target for Chemoprevention?-Reference-Cited by-同舟云学术

Regulation of Human Cytochrome P4501A1 (hCYP1A1): A Plausible Target for Chemoprevention?

Published:2016 Issue: Volume:2016 Page:1-17
ISSN:2314-6133
Container-title:BioMed Research International
language:en
Short-container-title:BioMed Research International

Author:

Santes-Palacios Rebeca¹,Ornelas-Ayala Diego¹,Cabañas Noel¹,Marroquín-Pérez Ana¹,Hernández-Magaña Alexis¹,del Rosario Olguín-Reyes Sitlali¹,Camacho-Carranza Rafael¹^ORCID,Espinosa-Aguirre Jesús Javier¹^ORCID

Affiliation:

1. Departamento de Medicina Genómica y Toxicología Ambiental, Instituto de Investigaciones Biomédicas, UNAM, Av. Universidad 3000, Col. Ciudad Universitaria, 04510 Ciudad de México, Mexico

Abstract

Human cytochrome P450 1A1 (hCYP1A1) has been an object of study due to its role in precarcinogen metabolism; for this reason it is relevant to know more in depth the mechanisms that rule out its expression and activity, which make this enzyme a target for the development of novel chemiopreventive agents. The aim of this work is to review the origin, regulation, and structural and functional characteristics of CYP1A1 letting us understand its role in the bioactivation of precarcinogen and the consequences of its modulation in other physiological processes, as well as guide us in the study of this important protein.

Funder

Consejo Nacional de Ciencia y Tecnología

Publisher

Hindawi Limited

Subject

General Immunology and Microbiology,General Biochemistry, Genetics and Molecular Biology,General Medicine

Link

http://downloads.hindawi.com/journals/bmri/2016/5341081.pdf

Reference152 articles.

1. CYTOCHROME P450-NULL MICE

2. Benzo[a]pyrene carcinogenicity is lost in mice lacking the aryl hydrocarbon receptor

3. Oral administration of the citrus coumarin, isopimpinellin, blocks DNA adduct formation and skin tumor initiation by 7,12-dimethylbenz[a]anthracene in SENCAR mice