Anti-Inflammatory Activity of Boswellia serrata Extracts: An In Vitro Study on Porcine Aortic Endothelial Cells

Author:

Bertocchi Martina1ORCID,Isani Gloria1ORCID,Medici Federica1,Andreani Giulia1ORCID,Tubon Usca Irvin1ORCID,Roncada Paola1,Forni Monica1ORCID,Bernardini Chiara1ORCID

Affiliation:

1. Department of Veterinary Medical Sciences-DIMEVET, University of Bologna, Ozzano Emilia, Bologna 40064, Italy

Abstract

This study is aimed at investigating the cytotoxicity, anti-inflammatory, and angiogenic activities of two Boswellia serrata extracts on primary culture of porcine aortic endothelial cells (pAECs). Chemical characterization of a dry extract (extract A) and a hydroenzymatic extract (extract G) of B. serrata was performed by HPLC using pure boswellic acids (BAs) as standard. In cultured pAECs, extract G improved cell viability, following LPS challenge, in a dose-dependent manner and did not show any toxic effect. On the other hand, extract A was toxic at higher doses and restored pAEC viability after LPS challenge only at lower doses. Pure BAs, used at the same concentrations as those determined in the phytoextracts, did not contrast LPS-induced cytotoxicity. Extract A showed proangiogenic properties at the lowest dose, and the same result was observed using pure AKBA at the corresponding concentration, whereas extract G did not show any effect on the migration capacity of endothelial cells. In conclusion, an anti-inflammatory activity of B. serrata extracts on endothelial cells was reported, though cytotoxicity or proliferative stimulation can occur instead of a protective effect, depending on the dose and the formulation.

Funder

Fondazione Cassa di Risparmio di Imola

Publisher

Hindawi Limited

Subject

Cell Biology,Aging,General Medicine,Biochemistry

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