Effect of Estragole on Leukocyte Behavior and Phagocytic Activity of Macrophages

Author:

Silva-Comar Francielli Maria de Souza1ORCID,Wiirzler Luiz Alexandre Marques1,Silva-Filho Saulo Euclides1,Kummer Raquel1,Pedroso Raissa Bocchi2,Spironello Ricardo Alexandre1,Silva Expedito Leite3,Bersani-Amado Ciomar Aparecida1,Cuman Roberto Kenji Nakamura1

Affiliation:

1. Department of Pharmacology and Therapeutics, State University of Maringá, Avenida Colombo 5790, 870020-900 Maringá, PR, Brazil

2. Department of Clinical Analyses, State University of Maringá, 870020-900 Maringá, PR, Brazil

3. Department of Chemistry, State University of Maringá, 870020-900 Maringá, PR, Brazil

Abstract

Estragole, a chemical constituent of the essential oils of many aromatic plants, is used as flavoring in beverage and food industries.In vivoandin vitroexperimental assays have shown that EST has sedative, anticonvulsant, antioxidant, antimicrobial, and anesthetic activity. In this work, we evaluate the effect of EST on leukocyte behavior and phagocytic activity of macrophages. In the peritonitis model, EST (500 and 750 mg/kg) decreased the infiltration of peritoneal exudate leukocytes.In vitrochemotaxis assay showed that EST (3, 10, 30, and 60 μg/mL) inhibited neutrophil migration toward fMLP. In thein vivomicrocirculation assay, EST at doses of 250, 500, and 750 mg/kg significantly reduced the number of rolling and adherent leukocytes and at doses of 250 and 500 mg/kg decreased number of leukocyte migrated to perivascular tissue. The results showed that EST (3, 10, and 30 μg/mL) was able to stimulate the macrophages phagocytosis but only at concentration of 10 μg/mL promoted an increase in nitric oxide (NO) production. In conclusion, this study showed that EST had potential anti-inflammatory effects, likely by inhibiting leukocyte migration and by stimulating macrophages phagocytosis.

Funder

Conselho Nacional de Desenvolvimento Científico e Tecnológico

Publisher

Hindawi Limited

Subject

Complementary and alternative medicine

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