Antibiotic-ResistantAcinetobacter baumanniiIncreasing Success Remains a Challenge as a Nosocomial Pathogen

Abstract

Antibiotic-resistant infectious bacteria currently imply a high risk and therefore constitute a strong challenge when treating patients in hospital settings. Characterization of these species and of particular strains is a priority for the establishment of diagnostic tests and preventive procedures. The relevance ofAcinetobacter baumanniias a problematic microorganism in inpatient facilities, particularly intensive care units, has increased over time. This review aims to draw attention to (i) the historical emergence of carbapenem-resistantAcinetobacter baumannii, (ii) the current status of surveillance needs in Latin America, and (iii) recent data suggesting thatA. baumanniicontinues to spread and evolve in hospital settings. First, we present synopsis of the series of events leading to the discovery and precise identification of this microorganism in hospital settings. Then key events in the acquisition of antibiotic-resistant genes by this microorganism are summarized, highlighting the race between new antibiotic generation and emergence ofA. baumanniiresistant strains. Here we review the historical development of this species as an infectious threat, the current state of its distribution, and antibiotic resistance characteristics, and we discuss future prospects for its control.