Exploring Host Genetic Polymorphisms Involved in SARS-CoV Infection Outcomes: Implications for Personalized Medicine in COVID-19

Author:

Ramos-Lopez Omar1ORCID,Daimiel Lidia2ORCID,Ramírez de Molina Ana3ORCID,Martínez-Urbistondo Diego4ORCID,Vargas Juan A.56ORCID,Martínez J. Alfredo78910ORCID

Affiliation:

1. Faculty of Medicine and Psychology, Autonomous University of Baja California, Tijuana, Baja California, Mexico

2. Nutritional Control of the Epigenome Group, IMDEA Food, CEI UAM + CSIC, Madrid, Spain

3. Molecular Oncology and Nutritional Genomics of Cancer, IMDEA-Food Institute, CEI UAM + CSIC, Madrid, Spain

4. Hospital Universitario HM Sanchinarro, Madrid, Spain

5. Servicio de Medicina Interna, Hospital Universitario Puerta de Hierro Majadahonda, Madrid, Spain

6. Facultad de Medicina, Departamento de Medicina, Universidad Autónoma de Madrid, Spain

7. Department of Nutrition, Food Science, Physiology and Toxicology, Centre for Nutrition Research, University of Navarra, Pamplona, Spain

8. Navarra Institute for Health Research (IdiSNA), Pamplona, Spain

9. Spanish Biomedical Research Centre in Physiopathology of Obesity and Nutrition (CIBERObn), Spain

10. Precision Nutrition and Cardiometabolic Health, Madrid Institute of Advanced Studies (IMDEA-Food Institute), Madrid, Spain

Abstract

Objective. To systematically explore genetic polymorphisms associated with the clinical outcomes in SARS-CoV infection in humans. Methods. This comprehensive literature search comprised available English papers published in PubMed/Medline and SCOPUS databases following the PRISMA-P guidelines and PICO/AXIS criteria. Results. Twenty-nine polymorphisms located in 21 genes were identified as associated with SARS-CoV susceptibility/resistance, disease severity, and clinical outcomes predominantly in Asian populations. Thus, genes implicated in key pathophysiological processes such as the mechanisms related to the entry of the virus into the cell and the antiviral immune/inflammatory responses were identified. Conclusions. Although caution must be taken, the results of this systematic review suggest that multiple genetic polymorphisms are associated with SARS-CoV infection features by affecting virus pathogenesis and host immune response, which could have important applications for the study and understanding of genetics in SARS-CoV-2/COVID-19 and for personalized translational clinical practice depending on the population studied and associated environments.

Publisher

Hindawi Limited

Subject

Pharmaceutical Science,Genetics,Molecular Biology,Biochemistry

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