Functional Roles of p38 Mitogen-Activated Protein Kinase in Macrophage-Mediated Inflammatory Responses

Author:

Yang Yanyan1,Kim Seung Cheol2ORCID,Yu Tao1,Yi Young-Su1ORCID,Rhee Man Hee3ORCID,Sung Gi-Ho4,Yoo Byong Chul5,Cho Jae Youl1ORCID

Affiliation:

1. Department of Genetic Engineering, Sungkyunkwan University, Suwon 440-746, Republic of Korea

2. Division of Gynecologic Oncology Department of Obstetrics and Gynecology, Ewha Womans University Mokdong Hospital College of Medicine, Ewha Womans University, Seoul 158-710, Republic of Korea

3. College of Veterinary Medicine, Kyungpook National University, Daegu 702-701, Republic of Korea

4. Department of Herbal Crop Research, National Institutes of Horticultural & Herbal Science, Rural Development Administration, Suwon 441-707, Republic of Korea

5. Colorectal Cancer Branch, Research Institute, National Cancer Center, Goyang, Gyeonggi 410-769, Republic of Korea

Abstract

Inflammation is a natural host defensive process that is largely regulated by macrophages during the innate immune response. Mitogen-activated protein kinases (MAPKs) are proline-directed serine and threonine protein kinases that regulate many physiological and pathophysiological cell responses. p38 MAPKs are key MAPKs involved in the production of inflammatory mediators, including tumor necrosis factor-α(TNF-α) and cyclooxygenase-2 (COX-2). p38 MAPK signaling plays an essential role in regulating cellular processes, especially inflammation. In this paper, we summarize the characteristics of p38 signaling in macrophage-mediated inflammation. In addition, we discuss the potential of using inhibitors targeting p38 expression in macrophages to treat inflammatory diseases.

Publisher

Hindawi Limited

Subject

Cell Biology,Immunology

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