Magnesium Oxide in Nanodimension: Model for MRI and Multimodal Therapy

Author:

Akram M. Waseem1ORCID,Fakhar-e-Alam Muhammad12ORCID,Butt Alvina Rafiq3ORCID,Munir T.2,Ali Akbar4,Alimgeer K. S.5ORCID,Mehmood-ur-Rehman Khalid6ORCID,Iqbal Seemab2,Ali Salamat3,Ikram Muhammad3,Amin N.2,Wang Zhiming M.1ORCID

Affiliation:

1. Institute of Fundamental and Frontier Science, University of Electronic Science and Technology of China, Chengdu 610054, China

2. Department of Physics, Government College University, Faisalabad 38000, Pakistan

3. Physics Department, Government College University (GCU), Lahore 54000, Pakistan

4. Department of Physics, COMSATS Institute of Information Technology, Lahore 54000, Pakistan

5. Department of Electrical Engineering, COMSATS Institute of Information Technology, Islamabad, Pakistan

6. School of Physics & Material Sciences, Anhui University, Hefei, China

Abstract

The prime focus of this investigation is to determine which morphology of magnesium oxide (MgO) is nontoxic and accumulates in sufficient quantity to a human brain cellular/tissue model. Thus, nanostructured MgO was synthesized from a coprecipitation technique involving twin synthetic protocols and the resulting product was characterized by scanning electron microscopy (SEM), transmission electron microscopy (TEM), size distribution histogram, Fourier-transform infrared spectroscopy (FTIR), and X-ray diffraction (XRD) analysis and elemental composition was confirmed by EDX analysis. They were tested for selective antigen response in a human brain cancer model through biodistribution, biotoxicity via MTT assay, and tissue morphology. In addition, the MRI compatibility of MgO nanostructures and immunofluorescence studies were investigated on nanoconjugates with different immunoglobulins in the brain section. The results indicated that MgO had some degree of bindings with the antigens. These results led to the empirical modeling of MgO nanomaterials towards toxicity in cancer cells by analyzing the statistical data obtained by experiments. All these results are providing new rational strategy with the concept of MgO for MRI and PTT/PDT.

Funder

Cambridge University

Publisher

Hindawi Limited

Subject

General Materials Science

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