Diagnosis Value of the Serum Amyloid A Test in Neonatal Sepsis: A Meta-Analysis

Author:

Yuan Haining1,Huang Jie2,Lv Bokun1,Yan Wenying13,Hu Guang1,Wang Jian2,Shen Bairong13

Affiliation:

1. Center for Systems Biology, Soochow University, Suzhou 215006, China

2. Affiliated Children's Hospital of Soochow University, Suzhou 225121, China

3. Suzhou Zhengxing Translational Biomedical Informatics Ltd., Taicang 215400, China

Abstract

Neonatal sepsis (NS), a common disorder for humans, is recognized as a leading global public health challenge. This meta-analysis was performed to assess the accuracy of the serum amyloid A (SAA) test for diagnosing NS. The studies that evaluated the SAA test as a diagnotic marker were searched in Pubmed, EMBASE, the Cochrane Library, and Google Network between January 1996 and June 2013. A total of nine studies including 823 neonates were included in our meta-analysis. Quality of each study was evaluated by the quality assessment of diagnostic accuracy studies tool (QUADAS). The SAA test showed moderate accuracy in the diagnosis of NS both at the first suspicion of sepsis and 8–96 h after the sepsis onset, both withQ*=0.91, which is similar to the PCT and CRP tests for the diagnosis of NS in the same period. Heterogeneity between studies was also explained by cut-off point, SAA assay, and age of included neonates. On the basis of our meta-analysis, therefore, SAA could be promising and meaningful in the diagnosis of NS.

Funder

National Natural Science Foundation of China

Publisher

Hindawi Limited

Subject

General Immunology and Microbiology,General Biochemistry, Genetics and Molecular Biology,General Medicine

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