Inflammatory Markers in Cord Blood for Early Diagnosis of Neonatal Sepsis

Abstract

This highlights the significance of early diagnosis of neonatal sepsis, a significant cause of neonatal mortality and morbidity. While blood culturing is the gold standard, inflammatory markers such as CRP, IL-6, and procalcitonin can aid in early diagnosis, particularly when using umbilical cord blood sampling. Maternal risk factors, including fever and prolonged labor, increase the risk of neonatal sepsis. Respiratory distress, lethargy, and feed intolerance are common presentations. The most frequently isolated organisms are Escherichia coli, Staphylococcus haemolyticus, and Klebsiella pneumonia. Combining inflammatory markers is recommended for better diagnosis, and timely detection of neonatal sepsis can reduce morbidity and mortality.