Preventive Effect ofZea maysL. (Purple Waxy Corn) on Experimental Diabetic Cataract

Author:

Thiraphatthanavong Paphaphat12,Wattanathorn Jintanaporn23,Muchimapura Supaporn23,Thukham-mee Wipawee23,Wannanon Panakaporn23,Tong-un Terdthai23,Suriharn Bhalang4,Lertrat Kamol4

Affiliation:

1. Department of Physiology and Graduate School (Neuroscience Program), Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand

2. Integrative Complementary Alternative Medicine Research and Development Center, Khon Kaen University, Khon Kaen 40002, Thailand

3. Department of Physiology, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand

4. Faculty of Agriculture, Khon Kaen University, Khon Kaen 40002, Thailand

Abstract

Recently, substances possessing antioxidant can prevent cataractogenesis of diabetic cataract. Therefore, this study was carried out to determine the anticataract effect ofZea maysL. (purple waxy corn), a flavonoids rich plant, in experimental diabetic cataract. Enucleated rat lenses were incubated in artificial aqueous humor containing 55 mM glucose with various concentrations ofZea maysL. (purple waxy corn) ranging between 2, 10, and 50 mg/mL at room temperature for 72 h. At the end of the incubation period, the evaluation of lens opacification, MDA level, and the activities of SOD, CAT, GPx, and AR in lens were performed. The results showed that both medium and high doses of extract decreased lens opacity together with the decreased MDA level. In addition, medium dose of extract increased GPx activity while the high dose decreased AR activity. No other significant changes were observed. The purple waxy corn seeds extract is the potential candidate to protect against diabetic cataract. The mechanism of action may occur via the decreased oxidative stress and the suppression of AR. However, further research in vivo is still essential.

Funder

Higher Education Research Promotion

Publisher

Hindawi Limited

Subject

General Immunology and Microbiology,General Biochemistry, Genetics and Molecular Biology,General Medicine

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