Author:
,Casco Nicolas,Jorge Alberto Levi,Palmero Domingo Juan,Alffenaar Jan-Willem,Fox Greg J.,Ezz Wafaa,Cho Jin-Gun,Denholm Justin,Skrahina Alena,Solodovnikova Varvara,Arbex Marcos Abdo,Alves Tatiana,Rabahi Marcelo Fouad,Pereira Giovana Rodrigues,Sales Roberta,Silva Denise Rossato,Saffie Muntasir M.,Salinas Nadia Escobar,Miranda Ruth Caamaño,Cisterna Catalina,Concha Clorinda,Fernandez Israel,Villalón Claudia,Vera Carolina Guajardo,Tapia Patricia Gallegos,Cancino Viviana,Carbonell Monica,Cruz Arturo,Muñoz Eduardo,Muñoz Camila,Navarro Indira,Pizarro Rolando,Cristina Sánchez Gloria Pereira,Vergara Riquelme Maria Soledad,Vilca Evelyn,Soto Aline,Flores Ximena,Garavagno Ana,Bahamondes Martina Hartwig,Merino Luis Moyano,Pradenas Ana María,Revillot Macarena Espinoza,Rodriguez Patricia,Salinas Angeles Serrano,Taiba Carolina,Valdés Joaquín Farías,Subiabre Jorge Navarro,Ortega Carlos,Palma Sofia,Castillo Patricia Perez,Pinto Mónica,Bidegain Francisco Rivas,Venegas Margarita,Yucra Edith,Li Yang,Cruz Andres,Guelvez Beatriz,Victoria Plaza Regina,Tello Hoyos Kelly Yoana,Cardoso-Landivar José,Van Den Boom Martin,Andréjak Claire,Blanc François-Xavier,Dourmane Samir,Froissart Antoine,Izadifar Armine,Rivière Frédéric,Schlemmer Frédéric,Manika Katerina,Diallo Boubacar Djelo,Hassane-Harouna Souleymane,Artiles Norma,Mejia Licenciada Andrea,Gupta Nitesh,Ish Pranav,Mishra Gyanshankar,Patel Jigneshkumar M.,Singla Rupak,Udwadia Zarir F.,Alladio Francesca,Angeli Fabio,Calcagno Andrea,Centis Rosella,Codecasa Luigi Ruffo,De Lauretis Angelo,Esposito Susanna M.R.,Formenti Beatrice,Gaviraghi Alberto,Giacomet Vania,Goletti Delia,Gualano Gina,Matteelli Alberto,Migliori Giovanni Battista,Motta Ilaria,Palmieri Fabrizio,Pontali Emanuele,Prestileo Tullio,Riccardi Niccolò,Saderi Laura,Saporiti Matteo,Sotgiu Giovanni,Spanevello Antonio,Stochino Claudia,Tadolini Marina,Torre Alessandro,Villa Simone,Visca Dina,Kurhasani Xhevat,Furjani Mohammed,Rasheed Najia,Danila Edvardas,Diktanas Saulius,Ridaura Ruy López,Luna López Fátima Leticia,Torrico Marcela Muñoz,Rendon Adrian,Akkerman Onno W.,Chizaram Onyeaghala,Al-Abri Seif,Alyaquobi Fatma,Althohli Khalsa,Aguirre Sarita,Teixeira Rosarito Coronel,De Egea Viviana,Irala Sandra,Medina Angélica,Sequera Guillermo,Sosa Natalia,Vázquez Fátima,Llanos-Tejada Félix K.,Manga Selene,Villanueva-Villegas Renzo,Araujo David,Sales Marques Raquel DuarteTânia,Socaci Adriana,Barkanova Olga,Bogorodskaya Maria,Borisov Sergey,Mariandyshev Andrei,Kaluzhenina Anna,Vukicevic Tatjana Adzic,Stosic Maja,Beh Darius,Ng Deborah,Ong Catherine W.M.,Solovic Ivan,Dheda Keertan,Gina Phindile,Caminero José A.,De Souza Galvão Maria Luiza,Dominguez-Castellano Angel,García-García José-María,Pinargote Israel Molina,Fernandez Sarai Quirós,Sánchez-Montalvá Adrián,Huguet Eva Tabernero,Murguiondo Miguel Zabaleta,Bart Pierre-Alexandre,Mazza-Stalder Jesica,D'Ambrosio Lia,Kamolwat Phalin,Bakko Freya,Barnacle James,Bird Sophie,Brown Annabel,Chandran Shruthi,Killington Kieran,Man Kathy,Papineni Padmasayee,Ritchie Flora,Tiberi Simon,Utjesanovic Natasa,Zenner Dominik,Hearn Jasie L.,Heysell Scott,Young Laura
Abstract
BackgroundLongitudinal cohort data of patients with tuberculosis (TB) and coronavirus disease 2019 (COVID-19) are lacking. In our global study, we describe long-term outcomes of patients affected by TB and COVID-19.MethodsWe collected data from 174 centres in 31 countries on all patients affected by COVID-19 and TB between 1 March 2020 and 30 September 2022. Patients were followed-up until cure, death or end of cohort time. All patients had TB and COVID-19; for analysis purposes, deaths were attributed to TB, COVID-19 or both. Survival analysis was performed using Cox proportional risk-regression models, and the log-rank test was used to compare survival and mortality attributed to TB, COVID-19 or both.ResultsOverall, 788 patients with COVID-19 and TB (active or sequelae) were recruited from 31 countries, and 10.8% (n=85) died during the observation period. Survival was significantly lower among patients whose death was attributed to TB and COVID-19versusthose dying because of either TB or COVID-19 alone (p<0.001). Significant adjusted risk factors for TB mortality were higher age (hazard ratio (HR) 1.05, 95% CI 1.03–1.07), HIV infection (HR 2.29, 95% CI 1.02–5.16) and invasive ventilation (HR 4.28, 95% CI 2.34–7.83). For COVID-19 mortality, the adjusted risks were higher age (HR 1.03, 95% CI 1.02–1.04), male sex (HR 2.21, 95% CI 1.24–3.91), oxygen requirement (HR 7.93, 95% CI 3.44–18.26) and invasive ventilation (HR 2.19, 95% CI 1.36–3.53).ConclusionsIn our global cohort, death was the outcome in >10% of patients with TB and COVID-19. A range of demographic and clinical predictors are associated with adverse outcomes.