Abstract
Question addressed by studyAdministration of aerosol to patients receiving high-flow nasal oxygen (HFNO) ranges from concurrent aerosol delivery by mouthpiece to aerosolviacannula alone. This study examines the conditions to provide optimal aerosol delivery with low- or high-flow nasal oxygen with concurrent mouthpiece or through nasal cannula alone, and the impact on fugitive aerosols.Materials and methodsA vibrating mesh nebuliser delivered salbutamolviamouthpiece, aerosol holding chamber and nasal cannula to an adult head model simulating relaxed breathing. The mean±sdinhaled dose (%) was assayed from a filter distal to the trachea. Optical particle sizers were used to measure fugitive aerosol concentrations during aerosol delivery.ResultsConcurrent low-flow nasal oxygen (LFNO) and aerosol delivery with a mouthpiece and aerosol holding chamber increased the inhaled dose (%) available, 31.44±1.33% when supplemented with 2 L·min−1of nasal oxygen. Concurrent HFNO above 30 L·min−1resulted in a lower inhaled dose (%) compared to aerosol delivered through HFNO alone. The addition of concurrent LFNO or HFNO resulted in no increase in aerosol levels in the test room.Answer to question posedConcurrent LFNO with a mouthpiece and aerosol holding chamber is an effective and safe means of aerosol delivery.
Publisher
European Respiratory Society (ERS)
Subject
Pulmonary and Respiratory Medicine
Cited by
7 articles.
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