In vitroactivity (MICs and rate of kill) of AFN-1252, a novel FabI inhibitor, in the presence of serum and in combination with other antibiotics-Reference-Cited by-同舟云学术

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In vitroactivity (MICs and rate of kill) of AFN-1252, a novel FabI inhibitor, in the presence of serum and in combination with other antibiotics

Published:2013-02 Issue:1 Volume:25 Page:18-25
ISSN:1120-009X
Container-title:Journal of Chemotherapy
language:en
Short-container-title:Journal of Chemotherapy

Author:

Kaplan Nachum,Awrey Donald,Bardouniotis Elias,Berman Judd,Yethon Jeremy,Pauls Henry W,Hafkin Barry

Publisher

Informa UK Limited

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology,Oncology

Link

http://www.tandfonline.com/doi/pdf/10.1080/10256018808623883

Reference15 articles.

1. Discovery of Aminopyridine-Based Inhibitors of Bacterial Enoyl-ACP Reductase (FabI)

2. Inhibitors of fatty acid synthesis as antimicrobial chemotherapeutics

3. Determination of Selectivity and Efficacy of Fatty Acid Synthesis Inhibitors

4. Inhibiting Bacterial Fatty Acid Synthesis

5. Inhibitors of FabI, an Enzyme Drug Target in the Bacterial Fatty Acid Biosynthesis Pathway

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1. Antibiotics with novel mode of action as new weapons to fight antimicrobial resistance;European Journal of Medicinal Chemistry;2023-08

2. A Long Residence Time Enoyl-Reductase Inhibitor Explores an Extended Binding Region with Isoenzyme-Dependent Tautomer Adaptation and Differential Substrate-Binding Loop Closure;ACS Infectious Diseases;2021-03-12

3. N-(1,3,4-Oxadiazol-2-yl)Benzamides as Antibacterial Agents against Neisseria gonorrhoeae;International Journal of Molecular Sciences;2021-02-28

4. Afabicin. Enoyl-(acyl-carrier-protein) reductase FabI inhibitor, Antibacterial drug;Drugs of the Future;2021

5. The genome of a Bacteroidetes inhabitant of the human gut encodes a structurally distinct enoyl-acyl carrier protein reductase (FabI);Journal of Biological Chemistry;2020-05

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