A Long Residence Time Enoyl-Reductase Inhibitor Explores an Extended Binding Region with Isoenzyme-Dependent Tautomer Adaptation and Differential Substrate-Binding Loop Closure

Author:

Eltschkner Sandra12,Kehrein Josef3,Le Thien Anh45,Davoodi Shabnam6,Merget Benjamin3,Basak Sneha6,Weinrich Jonas D.17,Schiebel Johannes1,Tonge Peter J.6,Engels Bernd4ORCID,Sotriffer Christoph3ORCID,Kisker Caroline1ORCID

Affiliation:

1. Rudolf Virchow Center for Integrative and Translational Bioimaging, Institute for Structural Biology, University of Würzburg, 97080 Würzburg, Germany

2. Molecular Ecology and Evolution Lab, Department of Biology, Lund University, 223 62 Lund, Sweden

3. Institute of Pharmacy and Food Chemistry, University of Würzburg, 97074 Würzburg, Germany

4. Institute of Physical and Theoretical Chemistry, University of Würzburg, 97074 Würzburg, Germany

5. Department of Experimental Physics 5 (Biophysics), University of Würzburg, 97074 Würzburg, Germany

6. Institute for Chemical Biology and Drug Discovery, Department of Chemistry, Stony Brook University, Stony Brook, New York 11794, United States

7. Department of Microbiology, Biocenter, University of Würzburg, 97074 Würzburg, Germany

Funder

Deutsche Forschungsgemeinschaft

National Institute of General Medical Sciences

Publisher

American Chemical Society (ACS)

Subject

Infectious Diseases

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3