Affiliation:
1. Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development, School of Chemistry and Molecular Engineering, East China Normal University, 3663 North Zhongshan Road, Shanghai 200062, China
Abstract
A practical and concise total synthesis of tricyclic ketone 7 (CDE ring), a valuable intermediate for the
synthesis of racemic camptothecin and analogs, was described (8 chemical steps and 29% overall yield). The
synthesis starts with two inexpensive, readily available materials and is operationally simple to perform. It is
worth mentioning that the reported protecting group-free synthesis, with advantages of a short route, would be
helpful for the future development of industry-scale syntheses of camptothecin-family alkaloids.
Funder
China Postdoctoral Science Foundation
Publisher
Bentham Science Publishers Ltd.
Subject
Organic Chemistry,Biochemistry