Evolution in medicinal chemistry of E-ring-modified Camptothecin analogs as anticancer agents

Author:

Huang Qingqing,Wang Lei,Lu Wei

Funder

The National Natural Science Foundation of China

The Shanghai Science and Technology Mission

Publisher

Elsevier BV

Subject

Organic Chemistry,Drug Discovery,Pharmacology,General Medicine

Reference133 articles.

1. Plant antitumor agents. I. The isolation and structure of camptothecin, a novel alkaloidal leukemia and tumor inhibitor from camptotheca acuminata;Wall;J. Am. Chem. Soc.,1966

2. Treatment of malignant melanoma with camptothecin (NSC-100880);Gottlieb;Cancer Chemother. Rep.,1972

3. Phase II study of camptothecin (NSC-100880) in the treatment of advanced gastrointestinal cancer;Moertel;Cancer Chemother. Rep.,1972

4. Phase I clinical trial of weekly and daily treatment with camptothecin (NSC-100880): correlation with preclinical studies;Muggia;Cancer Chemother. Rep.,1972

5. Camptothecin induces protein-linked DNA breaks via mammalian DNA topoisomerase I;Hsiang;J. Biol. Chem.,1985

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