Affiliation:
1. Institute of Pharmaceutical Research, GLA University, Mathura - 281406, Uttar Pradesh, India
Abstract
Abstract:
Rational design and synthesis of novel compounds with both effectivity and safety properties have always been a formidable task in the development of drugs. Oxadiazoles are heterocyclic bioscaf-folds occurring as motifs in drug-like molecules. This review article highlights comprehensive and sys-tematic information of compounds containing 1,2,4-oxadiazoles and 1,3,4-oxadiazole rings. The routes for the synthesis of the oxadiazoles have also been discussed, along with their biological significance. This review may help researchers in rational design for the development of effective and less toxic 1,3,4-oxadiazole based compounds. We present an informative review about the drugs derived from oxadiazole rings and their therapeutic application as well as a brief remark on the future development prospects.
Publisher
Bentham Science Publishers Ltd.
Subject
Organic Chemistry,Biochemistry
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