‘Convalescent Plasma’- An Effective Treatment Option to Prevent Emerging nCOVID-19- A Review

Author:

Ashique Sumel1ORCID,Khatun Tahamina2,Sahu Garima1,Upadhyay Aakash1,Adhana Archana1,Kumar Shubneesh1,Sandhu Navjot3,Kumar Nitish4

Affiliation:

1. Department of Pharmacy, Bharat Institute of Technology, (BIT), School of Pharmacy, Meerut-250103, Uttar Pradesh, India

2. Department of Life Science, Katiahat B.K.A.P Institution, West Bengal743427, India

3. Department of Quality Assurance, ISF College of Pharmacy, Moga, Punjab, India

4. Department of Pharmacology, SRM Modinagar College of Pharmacy, SRM Institute of Science and Technology (Deemed to be University), Delhi-NCR Campus, Modinagar, Ghaziabad, Uttar Pradesh-201204, India

Abstract

Abstract:To date, no accepted therapy exists for treating the emerging infectious disease nCOVID-19 in a safe and effective way. Although various types of treatment options are under the developing phase around the world, among those, several studies concerning convalescent plasma (CP) from recovered patients reported promising effects against nCOVID-19 infected critically ill patients nowadays. The therapy showed very few adverse effects, and it helps to diminish the viral load when administered at an early stage of infection. Convalescent plasma appears to be safe for critically ill nCOVID-19 patients by decreasing serum viral loads, and most cases are virus negative after CP transfusion. The convalescent plasma can be good as it has already been utilized to treat previous pandemics like Ebola, influenza, and SARS-CoV infection. In this review article, we pointed out the background, rationality, mechanisms, and safety outcomes of CP to treat nCOVID-19 infected patients.

Publisher

Bentham Science Publishers Ltd.

Subject

Microbiology (medical),Pharmacology,Molecular Medicine,General Medicine

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