Affiliation:
1. Division of Biological Sciences and Engineering, Netaji Subhas Institute of Technology, New Delhi, India
Abstract
Increased incidences of Candida infection have augmented morbidity and mortality in human
population, particularly among severely immunocompromised patients and those having a long stay in
hospitals (nosocomial infections). Many virulence factors and fitness attributes are reported to be associated
with the pathogenicity of Candida sp. It can cause infections ranging from easily treatable superficial
type to life-threatening invasive infections. Additionally, it has the capability to infect humans of all
age groups. Indeed, overutilization of broad-spectrum antibiotics has further complicated the scenario by
leading the emergence of less sensitive Candida strains especially non-albicans. Despite our developed
armamentarium, the diagnosis and treatment of human fungal infections remain a challenge.
This review focuses on the prevalence of Candida spp. as human pathogens with emerging resistance to
existing anti-fungal drugs. Furthermore, factors and mechanisms contributing to the pathogenicity of
Candida spp. and the challenges being faced in combating the devastating infections associated with
these pathogens have been discussed. Moreover, pros and cons of the current and future anti-mycotic
drugs have been analyzed.
Publisher
Bentham Science Publishers Ltd.
Subject
Drug Discovery,General Medicine
Cited by
47 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献