SARS-CoV-2 Omicron Variant in Medicinal Chemistry Research-Reference-Cited by-同舟云学术

SARS-CoV-2 Omicron Variant in Medicinal Chemistry Research

Published:2023-08-07 Issue:17 Volume:23 Page:1625-1639
ISSN:1568-0266
Container-title:Current Topics in Medicinal Chemistry
language:en
Short-container-title:CTMC

Author:

Souza Rocha Weslany¹,Zhan Peng²^ORCID,Ferreira da Silva-Júnior Edeildo³^ORCID

Affiliation:

1. Research Group on Biological and Molecular Chemistry, Institute of Chemistry and Biotechnology, Federal University of Alagoas, Maceió, 57072-970, Brazil

2. Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong University, Ji'nan, 250012, China

3. Research Group on Biological and Molecular Chemistry, Institute of Chemistry and Biotechnology, Federal University of Alagoas, Maceió, 57072-970, Brazil

Abstract

Abstract: The Coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respirato-ry syndrome Coronavirus 2 (SARS-CoV-2), has resulted in millions of deaths and threatens public health and safety. Nowadays, modern society has faced a new challenging problem, the emergence of novel SARS-CoV-2 variants of concern (VOCs). In this context, the Omicron (B.1.1.529) vari-ant, having more than 60 mutations when compared to its ancestral wild-type virus, has infected many individuals around the world. It is rapidly spread person-to-person due to its increased trans-missibility. Additionally, it was demonstrated that this newest variant and its subvariants have the capability of evading the host immune system, being resistant to neutralizing antibodies. Moreover, it has been proven to be resistant to monoclonal antibodies and several different vaccines. This abil-ity is associated with a huge number of mutations associated with its spike (S) glycoprotein, which presents at least 15 mutations. These mutations are able to modify the way how this virus interacts with the host angiotensin-converting enzyme 2 (ACE2), increasing its infectivity and making the therapeutic alternatives more ineffective. Concerning its chymotrypsin-like picornavirus 3C-like protease (3CLpro) and RNA-dependent RNA polymerase (RdRp), it has been seen that some com-pounds can be active against different SARS-CoV-2 variants, in a similar mode than its wild-type precursor. This broad spectrum of action for some drugs could be attributed to the fact that the cur-rently identified mutations found in 3CLpro and RNA proteins being localized near the catalytic binding site, conserving their activities. Herein this review, we provide a great and unprecedented compilation of all identified and/or repurposed compounds/drugs against this threatening variant, Omicron. The main targets for those compounds are the protein-protein interface (PPI) of S protein with ACE2, 3CLpro, RdRp, and Nucleocapsid (N) protein. Some of these studies have presented on-ly in silico data, having a lack of experimental results to prove their findings. However, these should be considered here since other research teams can use their observations to design and investigate new potential agents. Finally, we believe that our review will contribute to several studies that are in progress worldwide, compiling several interesting aspects about VOCs associated with SARS-CoV-2, as well as describing the results for different chemical classes of compounds that could be prom-ising as prototypes for designing new and more effective antiviral agents.

Publisher

Bentham Science Publishers Ltd.

Subject

Drug Discovery,General Medicine

Reference138 articles.

1. Volz E.; Hill V.; McCrone J.T.; Price A.; Jorgensen D.; O’Toole Á.; Southgate J.; Johnson R.; Jackson B.; Nascimento F.F.; Rey S.M.; Nicholls S.M.; Colquhoun R.M.; da Silva Filipe A.; Shepherd J.; Pascall D.J.; Shah R.; Jesudason N.; Li K.; Jarrett R.; Pacchiarini N.; Bull M.; Geidelberg L.; Siveroni I.; Goodfellow I.; Loman N.J.; Pybus O.G.; Robertson D.L.; Thomson E.C.; Rambaut A.; Connor T.R.; Koshy C.; Wise E.; Cortes N.; Lynch J.; Kidd S.; Mori M.; Fairley D.J.; Curran T.; McKenna J.P.; Adams H.; Fraser C.; Golubchik T.; Bonsall D.; Moore C.; Caddy S.L.; Khokhar F.A.; Wantoch M.; Reynolds N.; Warne B.; Maksimovic J.; Spellman K.; McCluggage K.; John M.; Beer R.; Afifi S.; Morgan S.; Marchbank A.; Price A.; Kitchen C.; Gulliver H.; Merrick I.; Southgate J.; Guest M.; Munn R.; Workman T.; Connor T.R.; Fuller W.; Bresner C.; Snell L.B.; Charalampous T.; Nebbia G.; Batra R.; Edgeworth J.; Robson S.C.; Beckett A.; Loveson K.F.; Aanensen D.M.; Underwood A.P.; Yeats C.A.; Abudahab K.; Taylor B.E.W.; Menegazzo M.; Clark G.; Smith W.; Khakh M.; Fleming V.M.; Lister M.M.; Howson-Wells H.C.; Berry L.; Boswell T.; Joseph A.; Willingham I.; Bird P.; Helmer T.; Fallon K.; Holmes C.; Tang J.; Raviprakash V.; Campbell S.; Sheriff N.; Loose M.W.; Holmes N.; Moore C.; Carlile M.; Wright V.; Sang F.; Debebe J.; Coll F.; Signell A.W.; Betancor G.; Wilson H.D.; Feltwell T.; Houldcroft C.J.; Eldirdiri S.; Kenyon A.; Davis T.; Pybus O.; du Plessis L.; Zarebski A.; Raghwani J.; Kraemer M.; Francois S.; Attwood S.; Vasylyeva T.; Torok M.E.; Hamilton W.L.; Goodfellow I.G.; Hall G.; Jahun A.S.; Chaudhry Y.; Hosmillo M.; Pinckert M.L.; Georgana I.; Yakovleva A.; Meredith L.W.; Moses S.; Lowe H.; Ryan F.; Fisher C.L.; Awan A.R.; Boyes J.; Breuer J.; Harris K.A.; Brown J.R.; Shah D.; Atkinson L.; Lee J.C.D.; Alcolea-Medina A.; Moore N.; Cortes N.; Williams R.; Chapman M.R.; Levett L.J.; Heaney J.; Smith D.L.; Bashton M.; Young G.R.; Allan J.; Loh J.; Randell P.A.; Cox A.; Madona P.; Holmes A.; Bolt F.; Price J.; Mookerjee S.; Rowan A.; Taylor G.P.; Ragonnet-Cronin M.; Nascimento F.F.; Jorgensen D.; Siveroni I.; Johnson R.; Boyd O.; Geidelberg L.; Volz E.M.; Brunker K.; Smollett K.L.; Loman N.J.; Quick J.; McMurray C.; Stockton J.; Nicholls S.; Rowe W.; Poplawski R.; Martinez-Nunez R.T.; Mason J.; Robinson T.I.; O’Toole E.; Watts J.; Breen C.; Cowell A.; Ludden C.; Sluga G.; Machin N.W.; Ahmad S.S.Y.; George R.P.; Halstead F.; Sivaprakasam V.; Thomson E.C.; Shepherd J.G.; Asamaphan P.; Niebel M.O.; Li K.K.; Shah R.N.; Jesudason N.G.; Parr Y.A.; Tong L.; Broos A.; Mair D.; Nichols J.; Carmichael S.N.; Nomikou K.; Aranday-Cortes E.; Johnson N.; Starinskij I.; da Silva Filipe A.; Robertson D.L.; Orton R.J.; Hughes J.; Vattipally S.; Singer J.B.; Hale A.D.; Macfarlane-Smith L.R.; Harper K.L.; Taha Y.; Payne B.A.I.; Burton-Fanning S.; Waugh S.; Collins J.; Eltringham G.; Templeton K.E.; McHugh M.P.; Dewar R.; Wastenge E.; Dervisevic S.; Stanley R.; Prakash R.; Stuart C.; Elumogo N.; Sethi D.K.; Meader E.J.; Coupland L.J.; Potter W.; Graham C.; Barton E.; Padgett D.; Scott G.; Swindells E.; Greenaway J.; Nelson A.; Yew W.C.; Resende Silva P.C.; Andersson M.; Shaw R.; Peto T.; Justice A.; Eyre D.; Crooke D.; Hoosdally S.; Sloan T.J.; Duckworth N.; Walsh S.; Chauhan A.J.; Glaysher S.; Bicknell K.; Wyllie S.; Butcher E.; Elliott S.; Lloyd A.; Impey R.; Levene N.; Monaghan L.; Bradley D.T.; Allara E.; Pearson C.; Muir P.; Vipond I.B.; Hopes R.; Pymont H.M.; Hutchings S.; Curran M.D.; Parmar S.; Lackenby A.; Mbisa T.; Platt S.; Miah S.; Bibby D.; Manso C.; Hubb J.; Chand M.; Dabrera G.; Ramsay M.; Bradshaw D.; Thornton A.; Myers R.; Schaefer U.; Groves N.; Gallagher E.; Lee D.; Williams D.; Ellaby N.; Harrison I.; Hartman H.; Manesis N.; Patel V.; Bishop C.; Chalker V.; Osman H.; Bosworth A.; Robinson E.; Holden M.T.G.; Shaaban S.; Birchley A.; Adams A.; Davies A.; Gaskin A.; Plimmer A.; Gatica-Wilcox B.; McKerr C.; Moore C.; Williams C.; Heyburn D.; De Lacy E.; Hilvers E.; Downing F.; Shankar G.; Jones H.; Asad H.; Coombes J.; Watkins J.; Evans J.M.; Fina L.; Gifford L.; Gilbert L.; Graham L.; Perry M.; Morgan M.; Bull M.; Cronin M.; Pacchiarini N.; Craine N.; Jones R.; Howe R.; Corden S.; Rey S.; Kumziene-Summerhayes S.; Taylor S.; Cottrell S.; Jones S.; Edwards S.; O’Grady J.; Page A.J.; Wain J.; Webber M.A.; Mather A.E.; Baker D.J.; Rudder S.; Yasir M.; Thomson N.M.; Aydin A.; Tedim A.P.; Kay G.L.; Trotter A.J.; Gilroy R.A.J.; Alikhan N.F.; de Oliveira Martins L.; Le-Viet T.; Meadows L.; Kolyva A.; Diaz M.; Bell A.; Gutierrez A.V.; Charles I.G.; Adriaenssens E.M.; Kingsley R.A.; Casey A.; Simpson D.A.; Molnar Z.; Thompson T.; Acheson E.; Masoli J.A.H.; Knight B.A.; Hattersley A.; Ellard S.; Auckland C.; Mahungu T.W.; Irish-Tavares D.; Haque T.; Bourgeois Y.; Scarlett G.P.; Partridge D.G.; Raza M.; Evans C.; Johnson K.; Liggett S.; Baker P.; Essex S.; Lyons R.A.; Caller L.G.; Castellano S.; Williams R.J.; Kristiansen M.; Roy S.; Williams C.A.; Dyal P.L.; Tutill H.J.; Panchbhaya Y.N.; Forrest L.M.; Niola P.; Findlay J.; Brooks T.T.; Gavriil A.; Mestek-Boukhibar L.; Weeks S.; Pandey S.; Berry L.; Jones K.; Richter A.; Beggs A.; Smith C.P.; Bucca G.; Hesketh A.R.; Harrison E.M.; Peacock S.J.; Palmer S.; Churcher C.M.; Bellis K.L.; Girgis S.T.; Naydenova P.; Blane B.; Sridhar S.; Ruis C.; Forrest S.; Cormie C.; Gill H.K.; Dias J.; Higginson E.E.; Maes M.; Young J.; Kermack L.M.; Hadjirin N.F.; Aggarwal D.; Griffith L.; Swingler T.; Davidson R.K.; Rambaut A.; Williams T.; Balcazar C.E.; Gallagher M.D.; O’Toole Á.; Rooke S.; Jackson B.; Colquhoun R.; Ashworth J.; Hill V.; McCrone J.T.; Scher E.; Yu X.; Williamson K.A.; Stanton T.D.; Michell S.L.; Bewshea C.M.; Temperton B.; Michelsen M.L.; Warwick-Dugdale J.; Manley R.; Farbos A.; Harrison J.W.; Sambles C.M.; Studholme D.J.; Jeffries A.R.; Darby A.C.; Hiscox J.A.; Paterson S.; Iturriza-Gomara M.; Jackson K.A.; Lucaci A.O.; Vamos E.E.; Hughes M.; Rainbow L.; Eccles R.; Nelson C.; Whitehead M.; Turtle L.; Haldenby S.T.; Gregory R.; Gemmell M.; Kwiatkowski D.; de Silva T.I.; Smith N.; Angyal A.; Lindsey B.B.; Groves D.C.; Green L.R.; Wang D.; Freeman T.M.; Parker M.D.; Keeley A.J.; Parsons P.J.; Tucker R.M.; Brown R.; Wyles M.; Constantinidou C.; Unnikrishnan M.; Ott S.; Cheng J.K.J.; Bridgewater H.E.; Frost L.R.; Taylor-Joyce G.; Stark R.; Baxter L.; Alam M.T.; Brown P.E.; McClure P.C.; Chappell J.G.; Tsoleridis T.; Ball J.; Grammatopoulos D.; Buck D.; Todd J.A.; Green A.; Trebes A.; MacIntyre-Cockett G.; de Cesare M.; Langford C.; Alderton A.; Amato R.; Goncalves S.; Jackson D.K.; Johnston I.; Sillitoe J.; Palmer S.; Lawniczak M.; Berriman M.; Danesh J.; Livett R.; Shirley L.; Farr B.; Quail M.; Thurston S.; Park N.; Betteridge E.; Weldon D.; Goodwin S.; Nelson R.; Beaver C.; Letchford L.; Jackson D.A.; Foulser L.; McMinn L.; Prestwood L.; Kay S.; Kane L.; Dorman M.J.; Martincorena I.; Puethe C.; Keatley J.P.; Tonkin-Hill G.; Smith C.; Jamrozy D.; Beale M.A.; Patel M.; Ariani C.; Spencer-Chapman M.; Drury E.; Lo S.; Rajatileka S.; Scott C.; James K.; Buddenborg S.K.; Berger D.J.; Patel G.; Garcia-Casado M.V.; Dibling T.; McGuigan S.; Rogers H.A.; Hunter A.D.; Souster E.; Neaverson A.S.; Evaluating the effects of SARS-CoV-2 spike mutation D614G on transmissibility and pathogenicity. Cell 2021,184(1),64-75.e11

2. Weng S.; Shang J.; Cheng Y.; Zhou H.; Ji C.; Yang R.; Wu A.; Genetic differentiation and diversity of SARS-CoV-2 Omicron variant in its early outbreak. Biosafety Health 2022,4(3),171-178

3. Sun Y.; Lin W.; Dong W.; Xu J.; Origin and evolutionary analysis of the SARS-CoV-2 Omicron variant. J Biosafety Biosec 2022,4(1),33-37

4. Viana R.; Moyo S.; Amoako D.G.; Tegally H.; Scheepers C.; Althaus C.L.; Anyaneji U.J.; Bester P.A.; Boni M.F.; Chand M.; Choga W.T.; Colquhoun R.; Davids M.; Deforche K.; Doolabh D.; du Plessis L.; Engelbrecht S.; Everatt J.; Giandhari J.; Giovanetti M.; Hardie D.; Hill V.; Hsiao N.Y.; Iranzadeh A.; Ismail A.; Joseph C.; Joseph R.; Koopile L.; Kosakovsky Pond S.L.; Kraemer M.U.G.; Kuate-Lere L.; Laguda-Akingba O.; Lesetedi-Mafoko O.; Lessells R.J.; Lockman S.; Lucaci A.G.; Maharaj A.; Mahlangu B.; Maponga T.; Mahlakwane K.; Makatini Z.; Marais G.; Maruapula D.; Masupu K.; Matshaba M.; Mayaphi S.; Mbhele N.; Mbulawa M.B.; Mendes A.; Mlisana K.; Mnguni A.; Mohale T.; Moir M.; Moruisi K.; Mosepele M.; Motsatsi G.; Motswaledi M.S.; Mphoyakgosi T.; Msomi N.; Mwangi P.N.; Naidoo Y.; Ntuli N.; Nyaga M.; Olubayo L.; Pillay S.; Radibe B.; Ramphal Y.; Ramphal U.; San J.E.; Scott L.; Shapiro R.; Singh L.; Smith-Lawrence P.; Stevens W.; Strydom A.; Subramoney K.; Tebeila N.; Tshiabuila D.; Tsui J.; van Wyk S.; Weaver S.; Wibmer C.K.; Wilkinson E.; Wolter N.; Zarebski A.E.; Zuze B.; Goedhals D.; Preiser W.; Treurnicht F.; Venter M.; Williamson C.; Pybus O.G.; Bhiman J.; Glass A.; Martin D.P.; Rambaut A.; Gaseitsiwe S.; von Gottberg A.; de Oliveira T.; Rapid epidemic expansion of the SARS-CoV-2 Omicron variant in southern Africa. Nature 2022,603(7902),679-686

5. Classification of Omicron (B.1.1.529): SARS-CoV-2 Variant of Concern. WHOAvailable From: [Accessed on Jul 6, 2022].

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