Nanoparticle Therapy for Prostate Cancer: Overview and Perspectives

Author:

Zhang Junfu1,Wang Liying2,You Xinru2,Xian Tuzeng3,Wu Jun2,Pang Jun1

Affiliation:

1. Department of Urology, The Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen, Guangdong, 518107, China

2. School of Biomedical Engineering, Sun Yat-sen University, Guangzhou, Guangdong 510006, China

3. Department of Urology, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, 510630, China

Abstract

Traditional prostate cancer therapy and especially chemotherapy has faced many challenges. Low accumulation levels, rapid clearance or drug resistance at the tumor site have been central to why the effect of chemotherapy drugs has declined. Applications of nanotechnology to biomedicine have enabled the development of nanoparticle therapeutic carriers suited for the delivery of chemotherapeutics in cancer therapy. This review describes the current nature of nanoparticle therapeutic carriers for prostate cancer. It describes typical nanocarriers commonly used for the delivery of chemotherapy or for imaging examination. Targeting strategies and related influencing factors are investigated to find ways of enhancing treatment effects of nanoparticles. The overall purpose of this review is to further understanding and to offer recommendations on the design and development of therapeutic nanoparticles for prostate cancer.

Funder

Science and Technology Planning Project of Shenzhen

Science and Technology Planning Project of Guangdong Province

Guangdong Innovative and Entrepreneurial Research Team Program

Thousand Talents Plan for Young Professionals, National Science and Technology Major Project of the Ministry of Science and Technology of China

The Key Research Project of Natural Science Foundation of Guangdong, China

Science and Technology Program of Guangzhou, China

Natural Science Foundation of Guangdong Province, China

National Natural Science Foundation of China

Publisher

Bentham Science Publishers Ltd.

Subject

Drug Discovery,General Medicine

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