Affiliation:
1. Department of Urology, The Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen, Guangdong, 518107, China
2. School of Biomedical Engineering, Sun Yat-sen University, Guangzhou, Guangdong 510006, China
3. Department of Urology, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, 510630, China
Abstract
Traditional prostate cancer therapy and especially chemotherapy has faced many challenges.
Low accumulation levels, rapid clearance or drug resistance at the tumor site have been central to why
the effect of chemotherapy drugs has declined. Applications of nanotechnology to biomedicine have enabled
the development of nanoparticle therapeutic carriers suited for the delivery of chemotherapeutics
in cancer therapy. This review describes the current nature of nanoparticle therapeutic carriers for prostate
cancer. It describes typical nanocarriers commonly used for the delivery of chemotherapy or for imaging
examination. Targeting strategies and related influencing factors are investigated to find ways of
enhancing treatment effects of nanoparticles. The overall purpose of this review is to further understanding
and to offer recommendations on the design and development of therapeutic nanoparticles for prostate
cancer.
Funder
Science and Technology Planning Project of Shenzhen
Science and Technology Planning Project of Guangdong Province
Guangdong Innovative and Entrepreneurial Research Team Program
Thousand Talents Plan for Young Professionals, National Science and Technology Major Project of the Ministry of Science and Technology of China
The Key Research Project of Natural Science Foundation of Guangdong, China
Science and Technology Program of Guangzhou, China
Natural Science Foundation of Guangdong Province, China
National Natural Science Foundation of China
Publisher
Bentham Science Publishers Ltd.
Subject
Drug Discovery,General Medicine
Cited by
37 articles.
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