Affiliation:
1. Department of Research, Sir Ganga Ram Hospital, New Delhi-110060, India
2. Gachon Institute of Pharmaceutical Science and Department of Pharmacy, College of Pharmacy, Gachon University, Incheon, Korea
Abstract
Glioma predominantly targets glial cells in the brain and spinal cord. There are grade I, II,
III, and IV gliomas with anaplastic astrocytoma and glioblastoma multiforme as the most severe
forms of the disease. Current diagnostic methods are limited in their data acquisition and interpretation,
markedly affecting treatment modalities, and patient outcomes. Circulating extracellular vesicles
(EVs) or “magic bullets” contain bioactive signature molecules such as DNA, RNA, proteins, lipids,
and metabolites. These secretory “smart probes” participate in myriad cellular activities, including
glioma progression. EVs are released by all cell populations and may serve as novel diagnostic biomarkers
and efficient nano-vehicles in the targeted delivery of encapsulated therapeutics. The present
review describes the potential of EV-based biomarkers for glioma management.
Funder
Gachon University of Medicine and Science
Publisher
Bentham Science Publishers Ltd.
Subject
Drug Discovery,General Medicine
Cited by
10 articles.
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