Affiliation:
1. Chitkara College of Pharmacy, Chitkara University, Punjab, India
2. Department of Regulatory Affairs, National Institute
of Pharmaceutical Education and Research (NIPER), Hyderabad, India
3. Centre for Chronic Disease, The University
of Queensland, Queensland, Australia
Abstract
Abstract:
Nature has provided therapeutic substances for millennia, with many valuable medications
derived from plant sources. Multitarget drugs become essential in the management of various
disorders, including hepatic disorders, neurological disorders, diabetes, and carcinomas. Ferulic
acid is a significant potential therapeutic agent, which is easily available at low cost, possesses a
low toxicity profile, and has minimum side effects. Ferulic acid exhibits various therapeutic actions
by modulation of various signal transduction pathways such as Nrf2, p38, and mTOR. The actions
exhibited by ferulic acid include anti-apoptosis, antioxidant, anti-inflammatory, antidiabetic, anticarcinogenic,
hepatoprotection, cardioprotection, activation of transcriptional factors, expression of
genes, regulation of enzyme activity, and neuroprotection, which further help in treating various
pathophysiological conditions such as cancer, skin diseases, brain disorders, diabetes, Parkinson’s
disease, Alzheimer’s disease, hypoxia, hepatic disorders, H1N1 flu, and viral infections. The current
review focuses on the significance of natural products as sources of multitarget compounds,
and a primary focus has been made on ferulic acid and its mechanism, role, and protective action in
various ailments.
Publisher
Bentham Science Publishers Ltd.
Subject
Drug Discovery,General Medicine