Affiliation:
1. Hubei Key Laboratory of Radiation Chemistry and Functional Materials, School of Nuclear Technology and Chemistry
& Biology, Hubei University of Science and Technology, Xianning, Hubei, P. R. China
Abstract
Abstract:
Bacterial infections, which cause a wide range of host immune disorders leading to local
and systemic tissue damage, are still one of the main causes of patient morbidity and mortality
worldwide. Treatment of bacterial infections is challenging, mainly attributed to the rapidly evolving
resistance mechanisms, creating an urgent demand to develop novel antibacterial agents. Hybridization
is one of the most promising strategies in the development of novel antibacterial drugs
with the potential to address drug resistance since different pharmacophores in the hybrid
molecules could modulate multiple targets and exert synergistic effects. Isatin, distributed widely
in nature, can exert antibacterial properties by acting on diverse enzymes, proteins, and receptors.
Accordingly, hybridization of isatin pharmacophores with other antibacterial pharmacophores in
one molecule may provide novel antibacterial candidates with broad-spectrum activity against various
pathogens, including drug-resistant forms. This review aims to outline the recent advances of
natural and synthetic isatin hybrids with antibacterial potential and summarizes the structure-activity
relationship (SAR) to provide an insight for the rational design of more active candidates, covering
articles published between January 2012 and June 2021.
Publisher
Bentham Science Publishers Ltd.
Subject
Drug Discovery,General Medicine
Cited by
8 articles.
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