Affiliation:
1. Universidade Federal Fluminense, Departamento de Quimica Organica, Programa de Pos-Graduacao em Quimica, Outeiro de Sao Joao Baptista, 24020-141 Niteroi, RJ, Brazil
Abstract
4-Oxoquinoline derivatives constitute an important family of biologically important substances,
associated with different bioactivities, which can be synthesized by different synthetic methods,
allowing the design and preparation of libraries of substances with specific structural variations capable
of modulating their pharmacological action. Over the last years, these substances have been extensively
explored by the scientific community in efforts to develop new biologically active agents, with greater
efficiency for the treatment of a variety of diseases. Viral infections have been one of the targets of
these studies, although to a lesser extent than other diseases such as cancer and bacterial infections.
Nevertheless, the literature provides examples that corroborate with the fact that these substances may
act on different pharmacological targets in different viral pathogens. This review provides a compilation
of some of the major studies published in recent years showing the discovery and/or development of
new antiviral oxoquinoline agents, highlighting, whenever possible, their mechanisms of action.
Publisher
Bentham Science Publishers Ltd.
Subject
Drug Discovery,General Medicine
Cited by
9 articles.
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