Therapeutic Targets and Computational Approaches on Drug Development for COVID-19-Reference-Cited by-同舟云学术

Therapeutic Targets and Computational Approaches on Drug Development for COVID-19

Published:2020-11-02 Issue:24 Volume:20 Page:2210-2220
ISSN:1568-0266
Container-title:Current Topics in Medicinal Chemistry
language:en
Short-container-title:CTMC

Author:

Shanmugam Anusuya¹,Muralidharan Nisha²,Velmurugan Devadasan³,Gromiha M. Michael²

Affiliation:

1. Department of Pharmaceutical Engineering, Vinayaka Mission’s KirupanandaVariyar Engineering College, Vinayaka Mission’s Research Foundation (Deemed to be University), Salem – 636308, Tamil Nadu, India

2. Department of Biotechnology, Bhupat and Jyoti Mehta School of Biosciences, Indian Institute of Technology Madras, Chennai – 600036, Tamil Nadu, India

3. Centre of Advanced Study in Crystallography and Biophysics, University of Madras, Guindy Campus, Chennai - 600025, India

Abstract

World Health Organization declared coronavirus disease (COVID-19) caused by SARS coronavirus-2 (SARS-CoV-2) as pandemic. Its outbreak started in China in Dec 2019 and rapidly spread all over the world. SARS-CoV-2 has infected more than 800,000 people and caused about 35,000 deaths so far, moreover, no approved drugs are available to treat COVID-19. Several investigations have been carried out to identify potent drugs for COVID-19 based on drug repurposing, potential novel compounds from ligand libraries, natural products, short peptides, and RNAseq analysis. This review is focused on three different aspects; (i) targets for drug design (ii) computational methods to identify lead compounds and (iii) drugs for COVID-19. It also covers the latest literature on various hit molecules proposed by computational methods and experimental techniques.

Funder

Science and Engineering Research Board

Publisher

Bentham Science Publishers Ltd.

Subject

Drug Discovery,General Medicine

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