Electrochemical Detector for Liquid Chromatography: Determining Minoxidil in Hair-Growth Pharmaceuticals-Reference-Cited by-同舟云学术

Electrochemical Detector for Liquid Chromatography: Determining Minoxidil in Hair-Growth Pharmaceuticals

Published:2019-07-12 Issue:5 Volume:15 Page:575-582
ISSN:1573-4110
Container-title:Current Analytical Chemistry
language:en
Short-container-title:CAC

Author:

Wang Lai-Hao¹,Cheng Pei-Tung¹

Affiliation:

1. Department of Medical Chemistry, Chia Nan University of Pharmacy and Science, 60 Erh-Jen Road, Section 1, Jen Te, Tainan 71743, Taiwan

Abstract

Background: The electrochemical behavior of minoxidil on gold (Au), Glassy Carbon (GCEs), and Carbon Paste Electrodes (CPEs) was investigated in an aqueous supporting electrolyte (phosphate buffer [pH 2.0-6.5], acetate buffer [pH 4.3], and Britton and Robinson buffer [pH 2.0-7.4]). Methods: For cyclic voltammetric measurements with suitable methodical parameters, CPEs catalyze electrooxidation of minoxidil more efficiently than do other electrodes. Minoxidil was detected using high-performance liquid chromatography with an electrochemical (carbon paste) detector (HPLCECD). For direct current mode, with the current at a constant potential, and measurements with suitable experimental parameters, a linear concentration from 0.02 to 2.6 mg L-1 was found. The detection limit was approximately 20 ng m L-1. Results: The developed method detected minoxidil samples. Conclusion: Findings using HPLC-ECD and HPLC with an ultraviolet detector were comparable.

Funder

Taiwan Ministry of Science and Technology

Publisher

Bentham Science Publishers Ltd.

Subject

Analytical Chemistry

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