New spectrophotometric methods for the determination of Minoxidil

Abstract

Minoxidil is a vasodilating agent used to treat pattern hair loss and resistant hypertension. New spectrophotometric techniques have been proposed for the estimation of Minoxidil in pharmaceutical dosage forms. Double beam Shimadzu Model UV-1800UV-VIS spectrophotometer was used for the present study. Minoxidil has shown linearity over the concentration range 0.1-20 µg/mL in distilled water, acetate buffer (pH 4.0), phosphate buffer (pH 5.8), borate buffer (pH 9.0), methanol and 0.1-15 µg/mL in phosphate buffer (pH 7.8) and the methods were validated as per ICH guidelines. The proposed methods are simple, economical and can be successfully applied for the assay of Minoxidil in pharmaceutical dosage forms.