Biomechanical Forces and Atherosclerosis: From Mechanism to Diagnosis and Treatment-Reference-Cited by-同舟云学术

Biomechanical Forces and Atherosclerosis: From Mechanism to Diagnosis and Treatment

Published:2020-09-10 Issue:3 Volume:16 Page:187-197
ISSN:1573-403X
Container-title:Current Cardiology Reviews
language:en
Short-container-title:CCR

Author:

Genkel Vadim V.¹^ORCID,Kuznetcova Alla S.²^ORCID,Shaposhnik Igor I.¹^ORCID

Affiliation:

1. Department of Internal Medicine, Federal State Budgetary Educational Institution of Higher Education “South-Ural State Medical University” of the Ministry of Healthcare of the Russian Federation, Chelyabinsk, Russian Federation

2. Department of Hospital Therapy Federal State Budgetary Educational Institution of Higher Education “South-Ural State Medical University” of the Ministry of Healthcare of the Russian Federation, Chelyabinsk, Russian Federation

Abstract

: The article provides an overview of current views on the role of biomechanical forces in the pathogenesis of atherosclerosis. The importance of biomechanical forces in maintaining vascular homeostasis is considered. We provide descriptions of mechanosensing and mechanotransduction. The roles of wall shear stress and circumferential wall stress in the initiation, progression and destabilization of atherosclerotic plaque are described. The data on the possibilities of assessing biomechanical factors in clinical practice and the clinical significance of this approach are presented. The article concludes with a discussion on current therapeutic approaches based on the modulation of biomechanical forces.

Publisher

Bentham Science Publishers Ltd.

Subject

Cardiology and Cardiovascular Medicine,General Medicine

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