Affiliation:
1. Department of Geriatrics, Tianjin Medical University General Hospital, Tianjin Geriatrics Institute, Tianjin, China
Abstract
Abstract:
As a sleep breathing disorder, characterized by intermittent hypoxia (IH) and Obstructive sleep
apnea (OSA), is believed to decrease the cognitive function of patients. Many factors are thought to be
responsible for cognitive decline in OSA patients. Neurogenesis, a process by which neural stem cells
(NSCs) differentiate into new neurons in the brain, is a major determinant affecting cognitive function.
However, there is no clear relationship between IH or OSA and neurogenesis. In recent years, increasing
numbers of studies on IH and neurogenesis are documented. Therefore, this review summarizes the effects
of IH on neurogenesis; then discusses the influencing factors that may cause these effects and the
potential signaling pathways that may exist. Finally, based on this impact, we discuss potential methods
and future directions for improving cognition.
Funder
Major Research Plan of National Natural Science Foundation of China
General Program of National Natural Science Foundation of China
Tianjin Science and Technology Plan Project
Tianjin Health Science and Technology Projects
Tianjin Key Medical Discipline (Specialty) Construction Project
Publisher
Bentham Science Publishers Ltd.
Subject
General Medicine,Medicine (miscellaneous)
Cited by
1 articles.
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