A brainwide atlas of synapses across the mouse life span-Reference-Cited by-同舟云学术

A brainwide atlas of synapses across the mouse life span

Published:2020-07-17 Issue:6501 Volume:369 Page:270-275
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Cizeron Mélissa¹²^ORCID,Qiu Zhen¹^ORCID,Koniaris Babis¹³^ORCID,Gokhale Ragini¹,Komiyama Noboru H.¹⁴^ORCID,Fransén Erik⁵⁶^ORCID,Grant Seth G. N.¹⁴^ORCID

Affiliation:

1. Genes to Cognition Program, Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh EH16 4SB, UK.

2. Institut NeuroMyoGène, Université de Lyon, Université Claude Bernard Lyon 1, CNRS UMR-5310, INSERM U-1217, 69008 Lyon, France.

3. School of Computing, Edinburgh Napier University, Edinburgh EH10 5DT, UK.

4. Simons Initiative for the Developing Brain (SIDB), Centre for Discovery Brain Sciences, University of Edinburgh, Edinburgh EH8 9XD, UK.

5. Department of Computational Science and Technology, School of Electrical Engineering and Computer Science, KTH Royal Institute of Technology, 10044 Stockholm, Sweden.

6. Science for Life Laboratory, KTH Royal Institute of Technology, SE-171 65 Solna, Sweden.

Abstract

Brain synapses through the life span Excitatory synapses connect neurons in the brain to build the circuits that enable behavior. Cizeron et al. surveyed synapses in the mouse brain from birth to old age and present the data as a community resource, the Mouse Lifespan Synaptome Atlas (see the Perspective by Micheva et al. ). Molecular and morphological features defined 37 subtypes of synapses. Although synapse density generally increased in early development and declined in old age, the details differed in different brain areas. Science this issue p. 270 ; see also p. 253

Funder

Wellcome

H2020 European Research Council

Simons Foundation Autism Research Initiative

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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