Affiliation:
1. Institute of Subtropical Agriculture, Chinese Academy of Sciences, Hunan, 410125, China
2. Shaodong Animal Husbandry and Fisheries Bureau, Hunan, 422800, China
Abstract
Background:
Deoxynivalenol contamination is increasing worldwide, presenting great challenges to food
security and causing great economic losses in the livestock industry.
Objective:
This study was conducted to determine the protective effect of baicalin zinc as a dietary supplement on
pigs fed with a deoxynivalenol contaminated diet.
Methods:
A total of 40 weaned pigs (21 d of age; 6.13 ± 0.42 kg average BW) were randomly assigned (10
pigs/group) to 4 dietary treatments: basal diet (Con group), basal diet + 4 mg/kg DON (DON group), basal diet +
5 g/kg BZN (BZN group), and basal diet + 5 g/kg BZN + 4 mg/kg DON (DBZN group) for a 14-d period. Seven
randomly-selected pigs from each treatment were killed for blood and tissue sampling.
Results:
The results showed that piglets challenged with DON exhibited significantly reduced levels of ADG, ADFI,
and F/G (p < 0.05). BZN supplemented diets significantly suppressed the protein expression of p-Nrf2, p-NF-kB, and
HO-1 in the jejunum of DON challenged piglets (p < 0.05). In liver, DON markedly increased the mRNA expression
of P70S6K and HSP70 in piglets fed the basal diet, but significantly reduced that of HO-1, NQO-1, NF-kB,
AMPKα2 and HSP70 in piglets fed the BZN supplemented diet (p < 0.05). Dietary supplementation with BZN
markedly increased the T-AOC level of serum in weaned piglets (p < 0.05). In jejunum, dietary supplementation with
BZN activated the mRNA expression of ZIP4 in piglets (p < 0.05), BZN supplementation significantly suppressed
the activity of sucrose and increased the protein concentration in chyme (p < 0.05).
Conclusion:
BZN can play a protective role by reducing oxidative stress and enhancing nutrient absorption in pigs
fed DON-contaminated diets.
Funder
Innovative Practice Training Program for College Students of Chinese Academy of Sciences
Chinese Academy of Sciences
Guangxi Zhuang Autonomous Region Science and Technology Department
Natural Science Foundation of Hunan Province
Publisher
Bentham Science Publishers Ltd.
Subject
Clinical Biochemistry,Pharmacology
Cited by
25 articles.
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