Current Strategies for Promoting the Large-scale Production of Exosomes-Reference-Cited by-同舟云学术

Current Strategies for Promoting the Large-scale Production of Exosomes

Published:2023-09 Issue:9 Volume:21 Page:1964-1979
ISSN:1570-159X
Container-title:Current Neuropharmacology
language:en
Short-container-title:CN

Author:

Qu Qing¹,Fu Bin¹,Long Yong¹,Liu Zi-Yu¹,Tian Xiao-Hong¹

Affiliation:

1. Department of Tissue Engineering, School of Intelligent Medicine, China Medical University, 77 Puhe Avenue, Shenbei New District, Shenyang, 110122, China

Abstract

Abstract: Exosomes, as nanoscale biological vesicles, have been shown to have great potential for biomedical applications. However, the low yield of exosomes limits their application. In this review, we focus on methods to increase exosome yield. Two main strategies are used to increase exosome production, one is based on genetic manipulation of the exosome biogenesis and release pathway, and the other is by pretreating parent cells, changing the culture method or adding different components to the medium. By applying these strategies, exosomes can be produced on a large scale to facilitate their practical application in the clinic.

Funder

Natural Science Foundation of Liaoning Province

Publisher

Bentham Science Publishers Ltd.

Subject

Pharmacology (medical),Psychiatry and Mental health,Neurology (clinical),Neurology,Pharmacology,General Medicine

Reference131 articles.

1. Zaborowski M.P.; Balaj L.; Breakefield X.O.; Lai C.P.; Extracellular vesicles: Composition, biological relevance, and methods of study. Bioscience 2015,65(8),783-797

2. Jeppesen D.K.; Fenix A.M.; Franklin J.L.; Higginbotham J.N.; Zhang Q.; Zimmerman L.J.; Liebler D.C.; Ping J.; Liu Q.; Evans R.; Fissell W.H.; Patton J.G.; Rome L.H.; Burnette D.T.; Coffey R.J.; Reassessment of Exosome Composition. Cell 2019,177(2),428-445.e18

3. Doyle L.; Wang M.; Overview of Extracellular vesicles, their origin, composition, purpose, and methods for exosome isolation and analysis. Cells 2019,8(7),727

4. Théry C.; Witwer K.W.; Aikawa E.; Alcaraz M.J.; Anderson J.D.; Andriantsitohaina R.; Antoniou A.; Arab T.; Archer F.; Atkin-Smith G.K.; Ayre D.C.; Bach J.M.; Bachurski D.; Baharvand H.; Balaj L.; Baldacchino S.; Bauer N.N.; Baxter A.A.; Bebawy M.; Beckham C.; Bedina Zavec A.; Benmoussa A.; Berardi A.C.; Bergese P.; Bielska E.; Blenkiron C.; Bobis-Wozowicz S.; Boilard E.; Boireau W.; Bongiovanni A.; Borràs F.E.; Bosch S.; Boulanger C.M.; Breakefield X.; Breglio A.M.; Brennan M.; Brigstock D.R.; Brisson A.; Broekman M.L.; Bromberg J.F.; Bryl-Górecka P.; Buch S.; Buck A.H.; Burger D.; Busatto S.; Buschmann D.; Bussolati B.; Buzás E.I.; Byrd J.B.; Camussi G.; Carter D.R.; Caruso S.; Chamley L.W.; Chang Y.T.; Chen C.; Chen S.; Cheng L.; Chin A.R.; Clayton A.; Clerici S.P.; Cocks A.; Cocucci E.; Coffey R.J.; Cordeiro-da-Silva A.; Couch Y.; Coumans F.A.; Coyle B.; Crescitelli R.; Criado M.F.; D’Souza-Schorey C.; Das S.; Datta Chaudhuri A.; de Candia P.; De Santana E.F.; De Wever O.; Del Portillo H.A.; Demaret T.; Deville S.; Devitt A.; Dhondt B.; Di Vizio D.; Dieterich L.C.; Dolo V.; Dominguez Rubio A.P.; Dominici M.; Dourado M.R.; Driedonks T.A.; Duarte F.V.; Duncan H.M.; Eichenberger R.M.; Ekström K.; El Andaloussi S.; Elie-Caille C.; Erdbrügger U.; Falcón-Pérez J.M.; Fatima F.; Fish J.E.; Flores-Bellver M.; Försönits A.; Frelet-Barrand A.; Fricke F.; Fuhrmann G.; Gabrielsson S.; Gámez-Valero A.; Gardiner C.; Gärtner K.; Gaudin R.; Gho Y.S.; Giebel B.; Gilbert C.; Gimona M.; Giusti I.; Goberdhan D.C.; Görgens A.; Gorski S.M.; Greening D.W.; Gross J.C.; Gualerzi A.; Gupta G.N.; Gustafson D.; Handberg A.; Haraszti R.A.; Harrison P.; Hegyesi H.; Hendrix A.; Hill A.F.; Hochberg F.H.; Hoffmann K.F.; Holder B.; Holthofer H.; Hosseinkhani B.; Hu G.; Huang Y.; Huber V.; Hunt S.; Ibrahim A.G.; Ikezu T.; Inal J.M.; Isin M.; Ivanova A.; Jackson H.K.; Jacobsen S.; Jay S.M.; Jayachandran M.; Jenster G.; Jiang L.; Johnson S.M.; Jones J.C.; Jong A.; Jovanovic-Talisman T.; Jung S.; Kalluri R.; Kano S.I.; Kaur S.; Kawamura Y.; Keller E.T.; Khamari D.; Khomyakova E.; Khvorova A.; Kierulf P.; Kim K.P.; Kislinger T.; Klingeborn M.; Klinke D.J.; Kornek M.; Kosanović M.M.; Kovács, Á. Minimal information for studies of extracellular vesicles 2018 (MISEV2018): A position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines. J Extracell Vesicles 2018,7(1),1535750

5. Wang J.; Yue B.L.; Huang Y.Z.; Lan X.Y.; Liu W.J.; Chen H.; Exosomal RNAs: Novel potential biomarkers for diseases—A review. Int J Mol Sci 2022,23(5),2461

Cited by 2 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Gastric cancer and mesenchymal stem cell-derived exosomes: from pro-tumorigenic effects to anti-cancer vehicles;Archives of Pharmacal Research;2023-12-27

2. Advances in RNA cancer therapeutics: New insight into exosomes as miRNA delivery;Aspects of Molecular Medicine;2023