Current Strategies for Promoting the Large-scale Production of Exosomes-Reference-Cited by-同舟云学术

Current Strategies for Promoting the Large-scale Production of Exosomes

Published:2023-09 Issue:9 Volume:21 Page:1964-1979
ISSN:1570-159X
Container-title:Current Neuropharmacology
language:en
Short-container-title:CN

Author:

Qu Qing¹,Fu Bin¹,Long Yong¹,Liu Zi-Yu¹,Tian Xiao-Hong¹

Affiliation:

1. Department of Tissue Engineering, School of Intelligent Medicine, China Medical University, 77 Puhe Avenue, Shenbei New District, Shenyang, 110122, China

Abstract

Abstract: Exosomes, as nanoscale biological vesicles, have been shown to have great potential for biomedical applications. However, the low yield of exosomes limits their application. In this review, we focus on methods to increase exosome yield. Two main strategies are used to increase exosome production, one is based on genetic manipulation of the exosome biogenesis and release pathway, and the other is by pretreating parent cells, changing the culture method or adding different components to the medium. By applying these strategies, exosomes can be produced on a large scale to facilitate their practical application in the clinic.

Funder

Natural Science Foundation of Liaoning Province

Publisher

Bentham Science Publishers Ltd.

Subject

Pharmacology (medical),Psychiatry and Mental health,Neurology (clinical),Neurology,Pharmacology,General Medicine

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