CA125: An Increasingly Promising Biomarker of Heart Failure

Author:

Pan Chunqi1ORCID,Zhou Mengyun2ORCID,Jian Ying1ORCID,Zeng Yuanyuan3ORCID,Wang Mingwei1ORCID,Chen Feng3ORCID

Affiliation:

1. Department of Cardiology, the Affiliated Hospital of Hangzhou Normal University, Hangzhou 310015, China

2. Department of Molecular & Cellular Physiology, Shinshu University School of Medicine, Asahi 390-8621, Japan

3. Pharmaceutical Sciences Research Center, Department of Pharmacy, Children’s Hospital of Nanjing Medical University, Nanjing 210008, China

Abstract

CA125 is a well-known tumor marker for diagnosis, monitoring, and risk stratification in ovarian cancer. It is not specific for malignant tumors and may be elevated in benign disease. In the past two decades, increasing evidence has emerged suggesting that the plasma level of CA125 can serve as a novel surrogate of heart failure (HF). CA125 in patients with HF is synthesized by serous epithelial cells in response to both mechanical and inflammatory stimuli. In patients with HF, regardless of etiology, CA125 levels correlate with the severity of clinical, hemodynamic, and echocardiographic parameters and with other biomarkers. Elevated CA125 can identify patients at high risk of rehospitalization and mortality, whether short- or long-term. Serial measurements and combination with different pathophysiology biomarkers can provide a more accurate prognosis value. It also can guide treatment as a robust biomarker of fluid overload and inflammation, particularly for diuretic dose optimization. These properties make it a very promising candidate for risk stratification and treatment guidance of HF.

Funder

Hangzhou Science and Technology Bureau Fund

Medical Science and Technique Foundation of Nanjing Health Commission

Specially Appointed Medical Expert Project of Jiangsu Commission of Health

Publisher

Bentham Science Publishers Ltd.

Subject

Drug Discovery,Pharmacology

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