Affiliation:
1. College of Medical Science, China Three Gorges University, Yichang 443002, China
Abstract
Background:
In recent decades, the incidence of obesity has been rising globally. Obesity can often
cause various inflammatory reactions, resulting in several diseases that threaten public health. The purpose of this
review is to explore the role of long non-coding RNAs in metabolic obesity and find new targets for the prevention
and treatment of metabolic diseases.
Methods:
We described the relationship between obesity and inflammation, reviewed several signaling pathways
in metabolic inflammation, and summarized some of the long non-coding RNAs and their targets associated with
metabolic inflammation. The related studies were retrieved through a systematic search of the PubMed database.
Result:
Metabolic stress during obesity can cause inflammation through several metabolic pathways. Many long
non-coding RNAs can affect the progression of metabolic inflammation by affecting different pathways.
Conclusion:
Downregulation or antagonization of long non-coding RNAs in metabolic pathways may provide
new ideas and therapeutic targets for the prevention and treatment of metabolic inflammation.
Funder
Health commission of Hubei Province scientific research project
National Natural Science Foundation of China
Publisher
Bentham Science Publishers Ltd.
Subject
Drug Discovery,Pharmacology
Cited by
6 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献