Bioavailability Enhancement of Poorly Soluble Drugs: The Holy Grail in Pharma Industry
-
Published:2019-07-09
Issue:9
Volume:25
Page:987-1020
-
ISSN:1381-6128
-
Container-title:Current Pharmaceutical Design
-
language:en
-
Short-container-title:CPD
Author:
Rashid Mamunur1, Malik Mohd Yaseen1, Singh Sandeep K.1, Chaturvedi Swati1, Gayen Jiaur R1, Wahajuddin Muhammad1
Affiliation:
1. Pharmaceutics and Pharmacokinetics Division, CSIR-CDRI, Lucknow, India
Abstract
Background:
Bioavailability, one of the prime pharmacokinetic properties of a drug, is defined as the
fraction of an administered dose of unchanged drug that reaches the systemic circulation and is used to describe
the systemic availability of a drug. Bioavailability assessment is imperative in order to demonstrate whether the
drug attains the desirable systemic exposure for effective therapy. In recent years, bioavailability has become
the subject of importance in drug discovery and development studies.
Methods:
A systematic literature review in the field of bioavailability and the approaches towards its enhancement
have been comprehensively done, purely focusing upon recent papers. The data mining was performed
using databases like PubMed, Science Direct and general Google searches and the collected data was exhaustively
studied and summarized in a generalized manner.
Results:
The main prospect of this review was to generate a comprehensive one-stop summary of the numerous
available approaches and their pharmaceutical applications in improving the stability concerns, physicochemical
and mechanical properties of the poorly water-soluble drugs which directly or indirectly augment their bioavailability.
Conclusion:
The use of novel methods, including but not limited to, nano-based formulations, bio-enhancers,
solid dispersions, lipid-and polymer-based formulations which provide a wide range of applications not only
increases the solubility and permeability of the poorly bioavailable drugs but also improves their stability, and
targeting efficacy. Although, these methods have drastically changed the pharmaceutical industry demand for the
newer potential methods with better outcomes in the field of pharmaceutical science to formulate various dosage
forms with adequate systemic availability and improved patient compliance, further research is required.
Funder
CSIR- Central Drug Research Institute Lucknow India communication
Publisher
Bentham Science Publishers Ltd.
Subject
Drug Discovery,Pharmacology
Reference432 articles.
1. Smolen VF, Weigand WA. J Pharmacokinet Biopharm, Drug bioavailability and pharmacokinetic analysis from pharmacological data.,, 1973, 1,, 329-336,[http://dx.doi.org/10.1007/BF01060040]. 2. Masaoka Y, Tanaka Y, Kataoka M, Sakuma S, Yamashita S. Eur J Pharm Sci, Site of drug absorption after oral administration: assessment of membrane permeability and luminal concentration of drugs in each segment of gastrointestinal tract.,, 2006, 29,, 240-250,[http://dx.doi.org/10.1016/j.ejps.2006.06.004]. [PMID: 16876987]. 3. . Eur J Pharm Sci, Health UDo, Services H. Bioanalytical Method Validation, Guidance
for Industry. ,, 2001, 29,, 240-, http://www.fda gov/cder/guidance/4252fnl htm. 4. Food S. Fed Regist, Drug Administration FDA guidance (152): Guidance for industry: evaluating the safety of antimicrobial new animal drugs with regard to their microbiological effects on bacteria of human health concern.,, 2003, 68,, 61221-, 5. Chiou WL. J Pharmacokinet Pharmacodyn, The rate and extent of oral bioavailability the rate and extent of oral absorption: clarification and recommendation of terminology.,, 2001, 28,, 3-6,[http://dx.doi.org/10.1023/A:1011544501243]. [PMID: 11253613].
Cited by
13 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献
|
|