Conversion of iota carrageenan hydrocolloids to hydrophobic hydrocolloids, by the replacement of potassium to barium ion, for the entrapment of water insoluble drugs

Abstract

AbstractTo entrap the water-insoluble medicine, the current innovation provides a cost-effective solution to the increasing need for hydrophobic gel. Improving the bioavailability of a medicine that is poorly soluble begins with entrapping the substance. By only switching out the monovalent ions for divalent ones, the researchers hope to increase the hydrophobicity of their material. In this experiment, barium ions were used instead of potassium ions in the iota carrageenan to make structural, chemical, and physicochemical changes easier during transformation. Hydrophobicity was determined qualitatively by observing the ability to trap small oil particles and repel water, moreover, the quantitative investigation was carried out using the weight loss method to determine the metal ion water isolation value and drug entrapment value within the core of barium linked carrageenan gel. The metal’s weight loss metal water affinity was determined to be 90% after 24 h, but it was only 67% with the synthesized gel coating the metal, this clearly shows that the barium gel had greater water protection activity. Furthermore, the barium-linked gel exhibited three times the entrapment capacity of the parent gel, and it successfully encased the water-insoluble medication with controlled release. The current study shows how the attached ion to the polymer changes its hydrophilic behavior into a hydrophobic one. This is a new and inexpensive way to do things. However, up until this point, the addition of the hydrophobic substrate and the functionalization of the polymer have been utilized. This leads to a plan that shows promise for improving the ability of hydrophobic hydrocolloid gels to hold drugs that do not dissolve in water.