Affiliation:
1. Department of Chemistry, Mirpur University of Science and Technology (MUST), 10250-Mirpur (AJK), Pakistan
Abstract
PABA (p-aminobenzoic acid) is an important substrate for the synthesis of various biological
scaffolds. Its pharmacological significance is apparent form the drugs like folic acid and benzocaine,
which are used for certain biological disorders. Although, it is not a vitamin but still it is referred
as a member of vitamin B. The deficiency of PABA leads to several disorders like erratic
white areas of skin, grey hair, fatigue, depression and irritability. Besides its medicinal importance,
PABA has been used in the synthesis of various biologically active heterocyclic nuclei like benzimidazoles,
azitidinones, thiazolidinones, pyrazoline, etc. This review will describe the applications of
PABA in the synthesis of these biologically active nuclei and hence emphasizing its importance as a
versatile substrate.
Publisher
Bentham Science Publishers Ltd.
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