Affiliation:
1. Nephrology Research Program, Department of Medicine, Department of Cellular and Molecular Physiology, The Pennsylvania State University College of Medicine, Hershey, PA, United States
Abstract
MicroRNAs (miRNAs) are small non-coding RNAs (19~25 nucleotides) that regulate
gene expression at a post-transcriptional level through repression of mRNA translation or mRNA
decay. MiR-147, which was initially discovered in mouse spleen and macrophages, has been
shown to correlate with coronary atherogenesis and inflammatory bowel disease and modulate
macrophage functions and inflammation through TLR-4. Altered miR-147 level has been shown in
various human diseases, including infectious disease, cancer, cardiovascular disease, neurodegenerative
disorder, etc. This review will focus on the current understanding regarding the role of
miR-147 in inflammation and diseases.
Funder
National Institutes of Health
Publisher
Bentham Science Publishers Ltd.
Subject
Orthopedics and Sports Medicine,Emergency Medicine,General Medicine
Cited by
12 articles.
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