Affiliation:
1. Department of Chemical Engineering, Shiraz Branch, Islamic Azad University, Shiraz, Iran
2. Department of Chemical Engineering, Qaemshahr Branch, Islamic Azad University, Qaemshahr, Iran
Abstract
Background:
Supercritical CO2 is the most applicable solvent because of its unique properties
such as; high selectivity, non-explosivity, non toxicity, low cost of purchasing and its unique
critical points. The solubility of this solvent changed rapidly with only a small change in pressure
and temperature especially in pressure. According to literatures, the method of supercritical extraction
is the best technology for extracting sensitive constituents. Despite of numerous studies in the
literature for extracting essential oil from plants, no studies can be found about this valuable medicinal
plant by CO2 supercritical extraction method.
Method:
In this study, the extraction of main medicinal constituents from Heracleum Persicum and
mathematical modeling was done using supercritical carbon dioxide. The experimental data were investigated
was analyzed by using gas chromatography (GC) and mass spectrometer chromatography
(GC-MS) methods. The model of seed and bed, which includes three parameters of mass transfer,
axial dispersion, and effective penetration coefficients, were used for modeling the extraction process.
This model was used based on the equilibrium of the fluid phase and solid phase to communicate
with the experimental data. Then the obtained yield of supercritical technology was compared
with the hydro distillation method.
Results:
The main extracted constituents of some different varieties of Heracleum by different
methods and solvents have been determined. The extracted chemicals by supercritical fluid technology
from the seeds of the Heracleum Persicum encompasses hexyl butanoate, octyl 2- methyl
butyrate, octylisobutyrate and anethole which are so effective against epilepsy and has the most antibacterial,
antiviral and antifungal effects. So supercritical fluid extraction is more selective than the
other methods.
Conclusion:
Extracting of essential oil and mathematical modeling from H. persicum were performed
under different operating conditions of temperature, pressure, particle size and solvent flow
rate. Experimental and modeling results showed that the operating parameters used in different conditions
had a different effect on extraction efficiency and model parameters.
Publisher
Bentham Science Publishers Ltd.
Subject
Complementary and alternative medicine,Drug Discovery
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