Affiliation:
1. Núcleo de Pesquisa em Ciências Exatas e Tecnológicas, Universidade de Franca, Franca, SP, Brazil
2. Instituto de
Química - Universidade Federal de Alfenas, MG, Brazil
3. Instituto de Ciências Biomédicas - Universidade Federal de
Alfenas, MG, Brazil
Abstract
Background:
Sclerotinia sclerotiorum is a phytopathogenic fungus from Sclerotinaceae
family. This fungus parasitizes approximately 400 species of plants of great economic importance,
such as soybean and beans. In this study, the anti-inflammatory properties of extracts, fractions, and
isolated compound ergosterol peroxide were investigated. The hexane fraction and 1 inhibited croton
oil-induced ear edema. In addition, ergosterol peroxide also inhibited neutrophil recruitment in the
myeloperoxidase assay, demonstrating that ergosterol peroxide exerts anti-inflammatory activity, inhibiting
the activity of both COX and LOX pathways. Moreover, these results provide new knowledge
regarding S. sclerotiorum as a source of extracts and bioactive compounds.
Objective::
The present study aimed to investigate the phytochemical profile of Sclerotinia sclerotiorum
and its in vivo anti-inflammatory activity.
Method:
The crude extract, fractions, and ergosterol peroxide of Sclerotinia sclerotiorum were evaluated
by croton oil-induced ear edema quantification of MPO (myeloperoxidase enzyme).
Results:
The crude extract and hexane fraction exhibited edema inhibition of 50.5 and 70.6%, respectively.
The ergosterol peroxide isolated from the hexane bioactive fractions exhibited significant inhibition
of ear edema, indicating inhibition of the COX pathway. In addition, ergosterol peroxide inhibited
neutrophil recruitment.
Conclusion:
The extract and fractions, as well as the isolated compound of Sclerotinia sclerotiorum,
exhibited anti-inflammatory potential.
Publisher
Bentham Science Publishers Ltd.
Subject
Complementary and alternative medicine,Drug Discovery
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