Cytotoxic Secondary Metabolites from the Ascomycetous Fungus Pseudogymnoascus roseus-Reference-Cited by-同舟云学术

Cytotoxic Secondary Metabolites from the Ascomycetous Fungus Pseudogymnoascus roseus

Published:2024-05-06 Issue: Volume:14 Page:
ISSN:2210-3155
Container-title:The Natural Products Journal
language:en
Short-container-title:NPJ

Author:

Lin Jie¹,He Yingchao²,Weng Ruofei¹,Jiao Jingru¹,Zheng Peixin¹,Dai Qun¹,Liu Ling³

Affiliation:

1. Jiangsu Key Laboratory for Biofunctional Molecules, College of Life Science and Chemistry, Jiangsu Second Normal University, Nanjing, 210013, People’s Republic of China

2. Department of neurology, Shengli Clinical Medical College of Fujian Medical University, Fujian Provincial Hospital, Fuzhou, People’s Republic of China

3. State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, 100101, People’s Republic of China; University of Chinese Academy of Sciences, Beijing, 100049, People’s Republic of China

Abstract

Background: Fungi found in unique and competitive environments are abundant in bioactive compounds. Objective: The objective of this study is to isolate and identify secondary metabolites from fungi of unique ecological niches and evaluate their cytotoxicity. Methods: The compounds were isolated and purified using silica gel column chromatography, Sephadex LH-20 gel chromatography, and semi-preparative high-performance liquid chromatography (HPLC). The structures of the isolated compounds were determined using NMR and MS. The cytotoxic activities of these compounds were tested by the MTS assay. Results: Three diphenyl ethers, dechlorodihydromaldoxin (1), violaceol-I (2) and violaceol-II (3), one quinolinone compound, 2-(2-heptenyl)-3-methyl-4(1H)-quinolinone (4), and one α-pyrone nafuredin (5) were isolated from the fermented extracts of Pseudogymnoascus roseus S161. Compound 1 showed modest cytotoxicity against two human tumor cell lines A549 and MCF-7, with IC50 values of 87.12 and 51.07 µM, respectively. Conclusion: Five compounds were isolated from the fungus P. roseus S161. Compound 1 showed moderate cytotoxicity. This study provided a basis for the development of antitumor drugs.

Publisher

Bentham Science Publishers Ltd.