Three Cases of Leber’s Hereditary Optic Neuropathy with Rapid Increase in Visual Acuity After Gene Therapy
Author:
Affiliation:
1. Department of Ophthalmology, Taihe Hospital, Hubei University of Medicine, Shiyan, Hubei Province, China
2. Department of Ophthalmology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
Abstract
Funder
Huazhong University of Science and Technology Horizontal Projects Fund
Huazhong University of Science and Technology Autonomous Innovation Fund
National Natural Science Foundation of China
Publisher
Bentham Science Publishers Ltd.
Subject
Genetics(clinical),Drug Discovery,Genetics,Molecular Biology,Molecular Medicine
Reference11 articles.
1. Chinnery PF. Leber hereditary optic neuropathy. J Med Genet Y-Wai-Man P. Turnbull DM2002,39,162-169
2. Peragallo J.H.; Newman N.J.; Is there treatment for Leber hereditary optic neuropathy? Curr Opin Ophthalmol 2015,26(6),450-457
3. Pilz Y.L.; Bass S.J.; Sherman J.; A review of mitochondrial optic neuropathies: from inherited to acquired forms. J Optom 2017,10(4),205-214
4. Wan X.; Pei H.; Zhao M.J.; Efficacy and safety of rAAV2-ND4 treatment for Leber’s hereditary optic neuropathy. Sci Rep 2016,6,21587
5. Guy J.; Feuer W.J.; Davis J.L.; Gene therapy for Leber hereditary optic neuropathy: Low- and medium-dose visual results. Ophthalmology 2017,124(11),1621-1634
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