Affiliation:
1. Department of Pharmaceutical Sciences, Maharshi Dayanand University, Rohtak-124001, India
2. Department of
Pharmaceutical Sciences, Chaudhary Bansi Lal University, Bhiwani-127021, India
Abstract
Abstract:
The majority of drugs taken orally have limited aqueous solubility and dissolution rate. Cyclodextrin
(CD) and its derivatives are used as pharmaceutical adjuvants, contributing to the development
of safe and high bioavailability formulations. CDs have a unique structure with a variety of
physicochemical features that aid pharmaceutical scientists in solving drug delivery issues for poorly
water-soluble drugs (PWS). This article covers information about cyclodextrin and its various derivatives,
its different manufacturing process, physicochemical properties, advantages, and recent advancements.
There are various advantages of CD-based inclusion complexes, such as enhancement of
solubility, bioavailability, and stability and reduction of irritation caused by the drug. Moreover, they
are used as odor and taste enhancers and also prevent incompatibility by physically isolating the incompatible
drug components in drug formulation. CD and its derivatives are extensively employed as
solubilizers in the manufacturing of parenteral and oral dosage forms. Inclusion complexes formed by
CDs with appropriately sized guest molecules improve drug water solubility, physical-chemical stability,
and bioavailability. Simultaneously CDs prevent the drugs from degradation like oxidation, hydrolysis,
and photodegradation and extend the shelf life of the drug. The manuscript also highlights
patents and exclusive branded formulations of modified CDs. It also discusses the different examples
of chemically modified CDs, i.e., captisol, sulfobutyl ether-β-CD, hydroxy propyl betadex, randomly
methylated β-CD, methyl β-CD, and hydoxy propyl γ-CD, all are used in the various dosage forms.
Publisher
Bentham Science Publishers Ltd.
Subject
Pharmaceutical Science,Biomedical Engineering
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