Affiliation:
1. Laboratory of Antimicrobial Chemotherapy, Faculty of Veterinary Medicine, “Ion Ionescu de la Brad” University of Life Sciences of Iasi (IULS), 8 Mihail Sadoveanu Alley, 700489 Iasi, Romania
2. Department of Surgery, Faculty of Dental Medicine, “Grigore T. Popa” University of Medicine and Pharmacy of Iasi, 16 Universitatii Street, 700115 Iași, Romania
Abstract
Cyclodextrins (CDs) are a family of carrier molecules used to improve the pharmacokinetic parameters of therapeutic molecules. These cyclic oligosaccharides have medical and pharmaceutical applications by being able to form inclusion complexes with molecules that are poorly soluble in water. The benefits of these complexes are directed towards improving the chemical and biological properties—i.e., solubility, bioavailability, stability, non-toxicity and shelf life of drug molecules. Since the 1960s, the first inclusion complexes used in therapeutics were those with α-, β- and γ-CD, which proved their usefulness, but had certain degrees of particularly renal toxicity. Currently, to correct these deficiencies, β-CD derivatives are most frequently used, such as sulfobutylether-β-CD, hydroxypropyl-β-CD, etc. Therefore, it is of interest to bring to the attention of those interested the diversity of current and potential future clinical applications of inclusion complexes in veterinary medicine and to present the contribution of these inclusion complexes in improving drug efficacy. The most important biological activities of β-CD complexed molecules in the veterinary field are summarized in this short review.
Subject
Chemistry (miscellaneous),Analytical Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Molecular Medicine,Drug Discovery,Pharmaceutical Science
Reference94 articles.
1. Han, Y., Liu, W., Huang, J., Qiu, S., Zhong, H., Liu, D., and Liu, J. (2018). Cyclodextrin-Based Metal-Organic Frameworks (CD-MOFs) in Pharmaceutics and Biomedicine. Pharmaceutics, 10.
2. Superbugs on Duodenoscopes: The Challenge of Cleaning and Disinfection of Reusable Devices;Humphries;J. Clin. Microbiol.,2015
3. Pharmaceutical Applications of Cyclodextrins: Effects on Drug Permeation through Biological Membranes;Loftsson;J. Pharm. Pharmacol.,2011
4. Pharmaceutical Applications of β-Cyclodextrin;Loftsson;Pharm. Technol. Eur.,1999
5. Cyclodextrins in Pharmaceutical Formulations I: Structure and Physicochemical Properties, Formation of Complexes, and Types of Complex;Jambhekar;Drug Discov. Today,2016
Cited by
1 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献