Affiliation:
1. Pharmaceutical Chemistry Department, School of Medical and Allied Sciences, GD Goenka University, Sohna, India
Abstract
Abstract:
Monoacylglycerol is a metabolic key serine hydrolase engaged in the regulation of the
signalling network system of endocannabinoids, which is associated with various physiological
processes like pain, inflammation, feeding cognition, and neurodegenerative diseases like Alzheimer’s
and Parkinson’s disease. The monoacylglycerol was also found to act as a regulator and
the free fatty acid provider in the proliferation of cancer cells as well as numerous aggressive tumours
such as colorectal cancer, neuroblastoma, and nasopharyngeal carcinoma. It also played an
important role in increasing the concentration of specific lipids derived from free fatty acids like
phosphatidic acid, lysophosphatidic acid, sphingosine-1-phosphate, and prostaglandin E2. These
signalling lipids are associated with cell proliferation, survival, tumour cell migration, contribution
to tumour development, maturation, and metastases. In this study, we present a review on structurally
diverse MAGL inhibitors, their development, and their evaluation for different pharmacological
activities.
Publisher
Bentham Science Publishers Ltd.
Subject
Psychiatry and Mental health
Cited by
5 articles.
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